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Br J Nutr

Title:		"Nutrigenetics of carotenoid metabolism in the chicken: a polymorphism at the beta,beta-carotene 15,15'-mono-oxygenase 1 (BCMO1) locus affects the response to dietary beta-carotene"
Author(s):		Jlali M; Graulet B; Chauveau-Duriot B; Godet E; Praud C; Nunes CS; Le Bihan-Duval E; Berri C; Duclos MJ;
Address:		"INRA, UR83 Recherches Avicoles, F-37380 Nouzilly, France. INRA, UMR1213 Herbivores, F-63122 Saint-Genes-Champanelle, France. INRA, UR83 Recherches Avicoles,F-37380Nouzilly,France. DSM Nutritional Products France, NRD/CA,BP 170, F-68305 Saint-Louis Cedex, France"
Journal Title:		Br J Nutr
Year:		2014
Volume:		20140318
Issue:		12
Page Number:		2079 - 2088
DOI:		10.1017/S0007114514000312
ISSN/ISBN:		1475-2662 (Electronic) 0007-1145 (Linking)
Abstract:		"The enzyme beta,beta-carotene-15,15'-mono-oxygenase 1 (BCMO1) is responsible for the symmetrical cleavage of beta-carotene into retinal. We identified a polymorphism in the promoter of the BCMO1 gene, inducing differences in BCMO1 mRNA levels (high in adenines (AA) and low in guanines (GG)) and colour in chicken breast muscle. The present study was designed to test whether this polymorphism could affect the response to dietary beta-carotene. Dietary beta-carotene supplementation did not change the effects of the genotypes on breast muscle properties: BCMO1 mRNA levels were lower and xanthophyll contents higher in GG than in AA chickens. Lower vitamin E levels in the plasma and duodenum, plasma cholesterol levels and body weight were also observed in GG than in AA chickens. In both genotypes, dietary beta-carotene increased vitamin A storage in the liver; however, it reduced numerous parameters such as SCARB1 (scavenger receptor class B type I) in the duodenum, BCMO1 in the liver, vitamin E levels in the plasma and tissues, xanthophyll contents in the pectoralis major muscle and carcass adiposity. However, several diet x genotype interactions were observed. In the GG genotype, dietary beta-carotene increased ISX (intestine-specific homeobox) and decreased BCMO1 mRNA levels in the duodenum, decreased xanthophyll concentrations in the duodenum, liver and plasma, and decreased colour index and HDL-cholesterol concentration in the plasma. Retinol accumulation following dietary beta-carotene supplementation was observed in the duodenum of AA chickens only. Therefore, the negative feedback control on beta-carotene conversion through ISX appears as functional in the duodenum of GG but not of AA chickens. This could result in a higher availability of beta-carotene in the duodenum of GG chickens, reducing the uptake of xanthophylls, liposoluble vitamins and cholesterol"
Keywords:		"Animals Carotenoids/*metabolism Chickens/genetics/growth & development/*metabolism Cholesterol, Dietary/metabolism Diet/*veterinary Duodenum/growth & development/metabolism Female France Genetic Association Studies/veterinary Homozygote Intestinal Absorpt;"
Notes:		"MedlineJlali, Maamer Graulet, Benoit Chauveau-Duriot, Beatrice Godet, Estelle Praud, Christophe Nunes, Carlos Simoes Le Bihan-Duval, Elisabeth Berri, Cecile Duclos, Michel J eng Research Support, Non-U.S. Gov't England 2014/03/20 Br J Nutr. 2014 Jun 28; 111(12):2079-88. doi: 10.1017/S0007114514000312. Epub 2014 Mar 18"