« Previous AbstractAssessing the role of mineral particles in the atmospheric photooxidation of typical carbonyl compound    Next AbstractDevelopment and comparison of methods using MS scan and selective ion monitoring modes for a wide range of airborne VOCs »

Brain Res

Title:		Calbindin D28K immunoreactive neurons in vomeronasal organ and their projections to the accessory olfactory bulb in the rat
Author(s):		Jia C; Halpern M;
Address:		"Department of Anatomy and Cell Biology, State University of New York Downstate Medical Center, Brooklyn, NY 11203, USA"
Journal Title:		Brain Res
Year:		2003
Volume:		977
Issue:		2
Page Number:		261 - 269
DOI:		10.1016/s0006-8993(03)02693-3
ISSN/ISBN:		0006-8993 (Print) 0006-8993 (Linking)
Abstract:		"The vomeronasal system is a nasal chemosensory system involved in pheromone detection. The chemosensory receptor neurons are located in the sensory epithelium of the vomeronasal organ (VNO). Their axons terminate in the glomeruli of the accessory olfactory bulb (AOB). In this study, we examined the expression of calbindin D28k (CB) in the rat VNO and AOB. In the VNO, a subpopulation of receptor neurons in the middle layer of the sensory epithelium was immunostained with antibodies to CB. Their axons could be traced to terminate in a group of glomeruli in the anterior half of the AOB glomerular layer. This group of CB-immunostained glomeruli in the anterior half of the AOB included a few large glomeruli close to the boundary between the anterior and posterior halves of the AOB, and several small glomeruli scattered in the anterior region of the AOB glomerular layer. The positions of the CB-immunostained glomeruli in the AOB, especially those close to the anterior-posterior boundary, were similar in the two bulbs and in different rats. No sex difference was found. A developmental study showed that the CB-immunoreactive receptor neurons in the middle layer of the VNO sensory epithelium and CB-immunoreactive glomeruli in the anterior AOB were present on the 14th postnatal day and older. The distribution pattern of the CB-immunostained receptor neurons and their localized projection suggest the possibility that these neurons may express the same or functionally related pheromone receptor genes"
Keywords:		"Aging Animals Animals, Newborn Calbindin 1 Calbindins Female GTP-Binding Protein alpha Subunit, Gi2 GTP-Binding Protein alpha Subunits, Gi-Go/metabolism Immunohistochemistry/methods Male Nasal Mucosa/metabolism Neural Pathways/*metabolism Neurons/metaboli;"
Notes:		"MedlineJia, Changping Halpern, Mimi eng DC 02745/DC/NIDCD NIH HHS/ Comparative Study Research Support, U.S. Gov't, P.H.S. Netherlands 2003/07/02 Brain Res. 2003 Jul 11; 977(2):261-9. doi: 10.1016/s0006-8993(03)02693-3"