| Title: | Neurotoxicity of fungal volatile organic compounds in Drosophila melanogaster |
| Author(s): | Inamdar AA; Masurekar P; Bennett JW; |
| Address: | "Department of Plant Biology and Pathology, Rutgers, The State University of New Jersey, New Brunswick, New Jersey 08901, USA. inamdar@rci.rutgers.edu" |
| ISSN/ISBN: | 1096-0929 (Electronic) 1096-0929 (Linking) |
| Abstract: | "Many volatile organic compounds (VOCs) are found in indoor environment as products of microbial metabolism. In damp indoor environments, fungi are associated with poor air quality. Some epidemiological studies have suggested that microbial VOCs have a negative impact on human health. Our study was designed to provide a reductionist approach toward studying fungal VOC-mediated toxicity using the inexpensive model organism, Drosophila melanogaster, and pure chemical standards of several important fungal VOCs. Low concentrations of the following known fungal VOCs, 0.1% of 1-octen-3-ol and 0.5% of 2-octanone; 2,5 dimethylfuran; 3-octanol; and trans-2-octenal, caused locomotory defects and changes in green fluorescent protein (GFP)- and antigen-labeled dopaminergic neurons in adult D. melanogaster. Locomotory defects could be partially rescued with L-DOPA. Ingestion of the antioxidant, vitamin E, improved the survival span and delayed the VOC-mediated changes in dopaminergic neurons, indicating that the VOC-mediated toxicity was due, in part, to generation of reactive oxygen species" |
| Keywords: | "Air Pollution/analysis Animals Dopamine/metabolism Drosophila melanogaster/*physiology Environmental Monitoring/methods Fungi/chemistry/*metabolism Green Fluorescent Proteins/metabolism Housing Levodopa/pharmacology Locomotion/drug effects Male Models, An;" |
| Notes: | "MedlineInamdar, Arati A Masurekar, Prakash Bennett, Joan Wennstrom eng Research Support, Non-U.S. Gov't 2010/07/21 Toxicol Sci. 2010 Oct; 117(2):418-26. doi: 10.1093/toxsci/kfq222. Epub 2010 Jul 19" |
