| Title: | The Impact of a Graded Maximal Exercise Protocol on Exhaled Volatile Organic Compounds: A Pilot Study |
| Author(s): | Heaney LM; Kang S; Turner MA; Lindley MR; Thomas CLP; |
| Address: | "School of Sport, Exercise and Health Sciences, Loughborough University, Loughborough LE11 3TU, UK. Centre for Analytical Science, Department of Chemistry, Loughborough University, Loughborough LE11 3TU, UK. Translational Chemical Biology Research Group, School of Sport, Exercise and Health Sciences, Loughborough University, Loughborough LE11 3TU, UK" |
| DOI: | 10.3390/molecules27020370 |
| ISSN/ISBN: | 1420-3049 (Electronic) 1420-3049 (Linking) |
| Abstract: | "Exhaled volatile organic compounds (VOCs) are of interest due to their minimally invasive sampling procedure. Previous studies have investigated the impact of exercise, with evidence suggesting that breath VOCs reflect exercise-induced metabolic activity. However, these studies have yet to investigate the impact of maximal exercise to exhaustion on breath VOCs, which was the main aim of this study. Two-litre breath samples were collected onto thermal desorption tubes using a portable breath collection unit. Samples were collected pre-exercise, and at 10 and 60 min following a maximal exercise test (VO(2MAX)). Breath VOCs were analysed by thermal desorption-gas chromatography-mass spectrometry using a non-targeted approach. Data showed a tendency for reduced isoprene in samples at 10 min post-exercise, with a return to baseline by 60 min. However, inter-individual variation meant differences between baseline and 10 min could not be confirmed, although the 10 and 60 min timepoints were different (p = 0.041). In addition, baseline samples showed a tendency for both acetone and isoprene to be reduced in those with higher absolute VO(2MAX) scores (mL(O(2))/min), although with restricted statistical power. Baseline samples could not differentiate between relative VO(2MAX) scores (mL(O(2))/kg/min). In conclusion, these data support that isoprene levels are dynamic in response to exercise" |
| Keywords: | *Volatile Organic Compounds VOCs exercise exhaled breath mass spectrometry metabolomics; |
| Notes: | "MedlineHeaney, Liam M Kang, Shuo Turner, Matthew A Lindley, Martin R Thomas, C L Paul eng Loughborough University Graduate School/Loughborough University/ Switzerland 2022/01/22 Molecules. 2022 Jan 7; 27(2):370. doi: 10.3390/molecules27020370" |
