| Title: | Differentiable detection of ethanol/methanol in biological fluids using prompt graphene-based electrochemical nanosensor coupled with catalytic complex of nickel oxide/8-hydroxyquinoline |
| Author(s): | Hashemi SA; Bahrani S; Mousavi SM; Omidifar N; Arjmand M; Lankarani KB; Shokripour M; Ramakrishna S; |
| Address: | "Nanomaterials and Polymer Nanocomposites Laboratory, School of Engineering, University of British Columbia, Kelowna, BC, V1V 1V7, Canada. Health Policy Research Center, Health Institute, Shiraz University of Medical Sciences, Shiraz, Iran. Department of Chemical Engineering, National Taiwan University of Science and Technology, Taiwan. Department of Pathology, Medical School, Shiraz University of Medical Sciences, Shiraz, Iran; Clinical Education Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. Electronic address: omidifarn@sums.ac.ir. Nanomaterials and Polymer Nanocomposites Laboratory, School of Engineering, University of British Columbia, Kelowna, BC, V1V 1V7, Canada. Electronic address: mohammad.arjmand@ubc.ca. Department of Pathology, Medical School, Shiraz University of Medical Sciences, Shiraz, Iran. Department of Mechanical Engineering, Center for Nanofibers and Nanotechnology, National University of Singapore, Singapore. Electronic address: seeram@nus.edu.sg" |
| DOI: | 10.1016/j.aca.2021.339407 |
| ISSN/ISBN: | 1873-4324 (Electronic) 0003-2670 (Linking) |
| Abstract: | "Serious health hazards of volatile organic compounds such as methanol and ethanol for living species and their adverse effects on the environment raised a global requirement for developing a portable, precise, and sensitive detection platform capable of simultaneous and differentiable detection of alcohols in aquatic biological and non-biological fluids. Each year, methanol toxicity causes serious healthcare problems and leads to high mortalities in developing countries. Hence, designing and developing a practical nanosensor for diagnostic applications and environmental monitoring is crucial. Herein, we have addressed this demand by fabricating a portable, ultra-sensitive, and precise nanosensor capable of simultaneous and differentiable detection of methanol and ethanol in any aquatic specimen in about 1 min. The nanosensor is composed of the integrated graphene oxide (GO) flakes with the catalytic complex of NiO(x) and 8-hydroxyquinoline (8HQ) capable of identification of methanol and ethanol with an analytical sensitivity/detection limit of 30.66 muA(mumol/mL)(-1).cm(-2)/6.87 nmol mL(-1) and 118.99 muA(mumol/mL)(-1).cm(-2)/1.80 nmol mL(-1) using voltammetric assays between the linear range of 0.014-0.01 mumol mL(-1) and 0.83-0.58 mumol mL(-1), respectively. The outcome of the assessments exhibited the favorable capability of the prepared nanosensor for precise/prompt detection of alcohols in blood specimens and showed an ideal correlation with the outcome of the gold standard" |
| Keywords: | Electrochemical Techniques Ethanol *Graphite Methanol Nickel Oxyquinoline Differentiable detection Graphene Sensor; |
| Notes: | "MedlineHashemi, Seyyed Alireza Bahrani, Sonia Mousavi, Seyyed Mojtaba Omidifar, Navid Arjmand, Mohammad Lankarani, Kamran Bagheri Shokripour, Mansoureh Ramakrishna, Seeram eng Netherlands 2022/01/23 Anal Chim Acta. 2022 Feb 15; 1194:339407. doi: 10.1016/j.aca.2021.339407. Epub 2021 Dec 29" |
