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Sci Rep

Title:		"Odorant-odorant metabolic interaction, a novel actor in olfactory perception and behavioral responsiveness"
Author(s):		Hanser HI; Faure P; Robert-Hazotte A; Artur Y; Duchamp-Viret P; Coureaud G; Heydel JM;
Address:		"Centre des Sciences du Gout et de l'Alimentation, UMR 6265 CNRS/1324 INRA/Universite de Bourgogne Franche-Comte, 9 boulevard Jeanne d'Arc, F-21000, Dijon, France. Centre de Recherche en Neurosciences de Lyon, INSERM U1028/CNRS UMR 5292/Universite Lyon 1, 50 avenue Tony Garnier, F-69007, Lyon, France. Centre de Recherche en Neurosciences de Lyon, INSERM U1028/CNRS UMR 5292/Universite Lyon 1, 50 avenue Tony Garnier, F-69007, Lyon, France. gerard.coureaud@cnrs.fr. Centre des Sciences du Gout et de l'Alimentation, UMR 6265 CNRS/1324 INRA/Universite de Bourgogne Franche-Comte, 9 boulevard Jeanne d'Arc, F-21000, Dijon, France. jean-marie.heydel@u-bourgogne.fr"
Journal Title:		Sci Rep
Year:		2017
Volume:		20170831
Issue:		1
Page Number:		10219 -
DOI:		10.1038/s41598-017-10080-z
ISSN/ISBN:		2045-2322 (Electronic) 2045-2322 (Linking)
Abstract:		"In the nasal olfactory epithelium, olfactory metabolic enzymes ensure odorant clearance from the olfactory receptor environment. This biotransformation of odorants into deactivated polar metabolites is critical to maintaining peripheral sensitivity and perception. Olfactory stimuli consist of complex mixtures of odorants, so binding interactions likely occur at the enzyme level and may impact odor processing. Here, we used the well-described model of mammary pheromone-induced sucking-related behavior in rabbit neonates. It allowed to demonstrate how the presence of different aldehydic odorants efficiently affects the olfactory metabolism of this pheromone (an aldehyde too: 2-methylbut-2-enal). Indeed, according to in vitro and ex vivo measures, this metabolic interaction enhances the pheromone availability in the epithelium. Furthermore, in vivo presentation of the mammary pheromone at subthreshold concentrations efficiently triggers behavioral responsiveness in neonates when the pheromone is in mixture with a metabolic challenger odorant. These findings reveal that the periphery of the olfactory system is the place of metabolic interaction between odorants that may lead, in the context of odor mixture processing, to pertinent signal detection and corresponding behavioral effect"
Keywords:		"Aldehydes/chemistry Animals Animals, Newborn Behavior, Animal/drug effects Complex Mixtures/chemistry Odorants/*analysis Olfactory Mucosa/*chemistry/enzymology Olfactory Perception/*physiology Pheromones/*analysis/chemistry Rabbits Smell Sucking Behavior/;neuroscience;"
Notes:		"MedlineHanser, Hassan-Ismail Faure, Philippe Robert-Hazotte, Aline Artur, Yves Duchamp-Viret, Patricia Coureaud, Gerard Heydel, Jean-Marie eng Research Support, Non-U.S. Gov't England 2017/09/02 Sci Rep. 2017 Aug 31; 7(1):10219. doi: 10.1038/s41598-017-10080-z"