| Title: | Insights into 'fermentonomics': evaluation of volatile organic compounds (VOCs) in human disease using an electronic 'e-nose' |
| Author(s): | Arasaradnam RP; Quraishi N; Kyrou I; Nwokolo CU; Joseph M; Kumar S; Bardhan KD; Covington JA; |
| Address: | "Warwick Medical School, University of Warwick, Coventry CV22DX, UK. R.Arasaradnam@warwick.ac.uk" |
| DOI: | 10.3109/03091902.2010.539770 |
| ISSN/ISBN: | 1464-522X (Electronic) 0309-1902 (Linking) |
| Abstract: | "Detection of volatile organic compounds (VOCs) is a common requirement in industry for which numerous methods are available. The electronic nose (e-nose) is an example. Rather than individual chemicals, the e-nose recognizes the 'aroma fingerprint' created by the collection of VOCs in samples, comparable to the human nose. We report on a novel application for gastrointestinal and metabolic medicine, and compare its results to mass spectrometry. Fermentation of undigested foods in the large bowel by its resident bacteria results in the creation of several chemicals including volatile gases that influence colonic and metabolic health. Using urine samples, preliminary results indicate the ability of the e-nose to distinguish between controls and those with inflammatory bowel disease or diabetes (separation rate of approximately 97%). This emphasizes the different patterns of fermentation. Our term 'fermentonomics' describes the investigation and analysis of the fermentome by such non-invasive means. Such an approach has potentially wide application in medicine" |
| Keywords: | Biosensing Techniques Electronics/*instrumentation Fermentation/physiology Humans Inflammatory Bowel Diseases/diagnosis/metabolism Volatile Organic Compounds/*analysis; |
| Notes: | "MedlineArasaradnam, R P Quraishi, N Kyrou, I Nwokolo, C U Joseph, M Kumar, S Bardhan, K D Covington, J A eng England 2011/01/06 J Med Eng Technol. 2011 Feb; 35(2):87-91. doi: 10.3109/03091902.2010.539770. Epub 2011 Jan 4" |
