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Environ Pollut

Title:		"Acute cardiovascular effects of traffic-related air pollution (TRAP) exposure in healthy adults: A randomized, blinded, crossover intervention study"
Author(s):		Han B; Zhao R; Zhang N; Xu J; Zhang L; Yang W; Geng C; Wang X; Bai ZD; Vedal S;
Address:		"State Key Laboratory of Environmental Criteria and Risk Assessment, Chinese Research Academy of Environmental Sciences, Beijing, 100012, China; Department of Environmental and Occupational Health Sciences, School of Public Health, University of Washington, Seattle, WA, 98105, USA. State Key Laboratory of Environmental Criteria and Risk Assessment, Chinese Research Academy of Environmental Sciences, Beijing, 100012, China. Department of Occupational and Environmental Health, School of Public Health, Tianjin Medical University, Tianjin, 300070, China. State Key Laboratory of Environmental Criteria and Risk Assessment, Chinese Research Academy of Environmental Sciences, Beijing, 100012, China; Department of Environmental and Occupational Health Sciences, School of Public Health, University of Washington, Seattle, WA, 98105, USA. Electronic address: baizp@craes.org.cn"
Journal Title:		Environ Pollut
Year:		2021
Volume:		20210701
Issue:
Page Number:		117583 -
DOI:		10.1016/j.envpol.2021.117583
ISSN/ISBN:		1873-6424 (Electronic) 0269-7491 (Linking)
Abstract:		"Exposure to traffic-related air pollution (TRAP) may enhance the risk of cardiovascular disease. However, the short-term effects of TRAP components on the cardiovascular system are not well understood. We conducted a randomized, double-blinded, crossover intervention study in which 39 healthy university students spent 2 h next to a busy road. Participants wore a powered air-purifying respirator (PAPR) or an N95 mask. PAPRs were equipped with a filter for particulate matter (PM), a PM and volatile organic compounds (VOCs) filter or a sham filter. Participants were blinded to PAPR filter type and underwent randomized exposures four times, once for each intervention mode. Blood pressure (BP), heart rate (HR) and heart rate variability (HRV) were measured before, during and for 6 h after the roadside exposure. Linear mixed-effect models were used to evaluate the effects of the interventions relative to baseline controlling for other covariates. All HRV measures increased during and following exposure for all intervention modes. Some HRV measures (SDNN and rMSSD during exposure and SDNN after exposure) were marginally affected by PM filtration. Wearing the N95 mask affected VLF power and rMSSD responses to traffic exposure differently than the PAPR interventions. Both systolic and diastolic BP increased slightly during exposure, but then were generally lower than baseline after exposure for the sham and filter interventions. HR, which fell during exposure and mostly remained lower than baseline after exposure, was lower yet with all filter interventions compared to the sham mode following exposure. Therefore, short-term exposure to traffic acutely affects HRV, BP and HR, but N95 mask and PAPR interventions generally show little efficacy in reducing these effects. Removing the PM component of TRAP has some limited effects on HRV responses to exposure but exaggerates the traffic-related decrease in HR. HRV findings from N95 mask interventions need to be interpreted cautiously"
Keywords:		Adult *Air Pollutants/analysis *Air Pollution/analysis *Cardiovascular System Cross-Over Studies Heart Rate Humans Particulate Matter/analysis *Traffic-Related Pollution Cardiovascular system Intervention study Respirator Traffic-related air pollution (TR;
Notes:		"MedlineHan, Bin Zhao, Ruojie Zhang, Nan Xu, Jia Zhang, Liwen Yang, Wen Geng, Chunmei Wang, Xinhua Bai, Zhipeng Dr Vedal, Sverre eng Randomized Controlled Trial England 2021/07/10 Environ Pollut. 2021 Nov 1; 288:117583. doi: 10.1016/j.envpol.2021.117583. Epub 2021 Jul 1"