Title: | Ambient exposures to selected volatile organic compounds and the risk of prostate cancer in Montreal |
Author(s): | Goldberg MS; Zapata-Marin S; Labreche F; Ho V; Lavigne E; Valois MF; Parent ME; |
Address: | "Department of Medicine, McGill University, Montreal, Quebec, Canada. Centre for Outcomes Research and Evaluation, Research Institute of the McGill University Hospital Centre, Montreal, Quebec, Canada. Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, Quebec, Canada. Institut de Recherche Robert-Sauve en Sante et en Securite du Travail, Montreal, Quebec, Canada. Department of Environmental and Occupational Health, School of Public Health, Universite de Montreal, Montreal, Quebec, Canada. Centre de recherche en sante publique (CReSP), University of Montreal and CIUSSS Centre-Sud, Montreal, Quebec, Canada. Department of Social and Preventive Medicine, School of Public Health, Universite de Montreal, Montreal, Quebec, Canada. Health Innovation and Evaluation Hub, Universite de Montreal Hospital Research Centre (CRCHUM), Montreal, Canada. Health Canada, Air Health Science Division, Ottawa, Ontario, Canada. Department of Epidemiology, Public Health and Preventive Medicine, University of Ottawa, Ottawa, Ontario, Canada. Centre Armand-Frappier Sante Biotechnologie, Institut national de la recherche scientifique, Universite du Quebec, Laval, Quebec, Canada" |
DOI: | 10.1097/EE9.0000000000000231 |
ISSN/ISBN: | 2474-7882 (Electronic) 2474-7882 (Linking) |
Abstract: | "Little is known about environmental factors that may increase the risk of prostate cancer. We estimated associations between incident prostate cancer and environmental concentrations of five ambient volatile organic compounds (VOCs): benzene; n-decane; ethylbenzene; hexane; and 1,2,4-trimethylbenzene. METHODS: This study is based on a population-based case-control study of incident prostate cancer (PROtEuS) in men = 75 years of age living in Montreal, Canada, in 2005 to 2012. We included 1172 cases and 1177 population controls. We had personal information, lifetime residential addresses, occupational exposures, and a variety of area-wide covariables. We inferred concentrations of the five VOCs using Bayesian geostatistical models using data from a dense environmental survey conducted in Montreal in 2005 to 2006. We used different sets of adjustments to estimate odds ratios (OR) and confidence intervals. RESULTS: We found nonlinear associations such that the ORs increased monotonically and then either flattened or fell off with increased exposures. The model that contained other environmental variables and contextual variables led to lower ORs and results were similar when we restricted analyses to controls recently screened or tested for prostate cancer or cases with low- or high-grade tumors. A change from the 5th to 25th percentile in mean environmental benzene levels led to an adjusted OR of 2.00 (95% confidence interval = 1.47, 2.71). CONCLUSION: We found positive associations between prostate cancer and concentrations of benzene and ethylbenzene, independently of previous testing for prostate cancer or tumor grade, suggesting that exposure to certain ambient VOCs may increase incidence" |
Keywords: | "1, 2, 4-Trimethylbenzene Benzene Case-control study Ethylbenzene Hexane Population-based Prostate cancer Volatile organic compounds n-Decane;" |
Notes: | "PubMed-not-MEDLINEGoldberg, Mark S Zapata-Marin, Sara Labreche, France Ho, Vikki Lavigne, Eric Valois, Marie-France Parent, Marie-Elise eng 2022/12/20 Environ Epidemiol. 2022 Nov 9; 6(6):e231. doi: 10.1097/EE9.0000000000000231. eCollection 2022 Dec" |