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Genome Res

Title:		Comparative evolutionary genomics of androgen-binding protein genes
Author(s):		Emes RD; Riley MC; Laukaitis CM; Goodstadt L; Karn RC; Ponting CP;
Address:		"MRC Functional Genetics Unit, Department of Human Anatomy and Genetics, University of Oxford, Oxford OX1 3QX, United Kingdom"
Journal Title:		Genome Res
Year:		2004
Volume:		20040715
Issue:		8
Page Number:		1516 - 1529
DOI:		10.1101/gr.2540304
ISSN/ISBN:		1088-9051 (Print) 1088-9051 (Linking)
Abstract:		"Allelic variation within the mouse androgen-binding protein (ABP) alpha subunit gene (Abpa) has been suggested to promote assortative mating and thus prezygotic isolation. This is consistent with the elevated evolutionary rates observed for the Abpa gene, and the Abpb and Abpg genes whose products (ABPbeta and ABPgamma) form heterodimers with ABPalpha. We have investigated the mouse sequence that contains the three Abpa/b/g genes, and orthologous regions in rat, human, and chimpanzee genomes. Our studies reveal extensive 'remodeling' of this region: Duplication rates of Abpa-like and Abpbg-like genes in mouse are >2 orders of magnitude higher than the average rate for all mouse genes; synonymous nucleotide substitution rates are twofold higher; and the Abpabg genomic region has expanded nearly threefold since divergence of the rodents. During this time, one in six amino acid sites in ABPbetagamma-like proteins appear to have been subject to positive selection; these may constitute a site of interaction with receptors or ligands. Greater adaptive variation among Abpbg-like sequences than among Abpa-like sequences suggests that assortative mating preferences are more influenced by variation in Abpbg-like genes. We propose a role for ABPalpha/beta/gamma proteins as pheromones, or in modulating odorant detection. This would account for the extraordinary adaptive evolution of these genes, and surrounding genomic regions, in murid rodents"
Keywords:		"Amino Acid Sequence Androgen-Binding Protein/chemistry/*genetics Animals Base Sequence Cats *Evolution, Molecular Glycoproteins/chemistry/genetics Humans Mice Models, Molecular Molecular Sequence Data Phylogeny Physical Chromosome Mapping Protein Structur;"
Notes:		"MedlineEmes, Richard D Riley, Matthew C Laukaitis, Christina M Goodstadt, Leo Karn, Robert C Ponting, Chris P eng Comparative Study Research Support, Non-U.S. Gov't 2004/07/17 Genome Res. 2004 Aug; 14(8):1516-29. doi: 10.1101/gr.2540304. Epub 2004 Jul 15"