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G3 (Bethesda)

Title:		Formation and function of dauer ascarosides in the nematodes Caenorhabditis briggsae and Caenorhabditis elegans
Author(s):		Cohen SM; Wrobel CJJ; Prakash SJ; Schroeder FC; Sternberg PW;
Address:		"Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA. Boyce Thompson Institute and Department of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14853, USA"
Journal Title:		G3 (Bethesda)
Year:		2022
Volume:		12
Issue:		3
Page Number:		-
DOI:		10.1093/g3journal/jkac014
ISSN/ISBN:		2160-1836 (Electronic) 2160-1836 (Linking)
Abstract:		"The biosynthetic pathways and functions of ascaroside signaling molecules in the nematode Caenorhabditis elegans have been studied to better understand complex, integrative developmental decision-making. Although it is known that ascarosides play multiple roles in the development and behavior of nematode species other than C. elegans, these parallel pheromone systems have not been well-studied. Here, we show that ascarosides in the nematode Caenorhabditis briggsae are biosynthesized in the same manner as C. elegans and act to induce the alternative developmental pathway that generates the stress-resistant dauer lifestage. We show that ascr#2 is the primary component of crude dauer pheromone in C. briggsae; in contrast, C. elegans dauer pheromone relies on a combination of ascr#2, ascr#3, and several other components. We further demonstrate that Cbr-daf-22, like its C. elegans ortholog Cel-daf-22, is necessary to produce short-chain ascarosides. Moreover, Cbr-daf-22 and Cel-daf-22 mutants produce an ascaroside-independent metabolite that acts antagonistically to crude dauer pheromone and inhibits dauer formation"
Keywords:		Animals *Caenorhabditis/genetics/metabolism Caenorhabditis elegans/metabolism *Caenorhabditis elegans Proteins/genetics/metabolism Larva/metabolism Pheromones Signal Transduction C.briggsae C.elegans daf-22 glo-1 ascarosides dauer;
Notes:		"MedlineCohen, Sarah M Wrobel, Chester J J Prakash, Sharan J Schroeder, Frank C Sternberg, Paul W eng P40 OD010440/OD/NIH HHS/ R01 GM113692/GM/NIGMS NIH HHS/ R24 OD023041/OD/NIH HHS/ UF1 NS111697/NS/NINDS NIH HHS/ R35 GM131877/GM/NIGMS NIH HHS/ Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't England 2022/01/31 G3 (Bethesda). 2022 Mar 4; 12(3):jkac014. doi: 10.1093/g3journal/jkac014"