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Vet Res Commun

Title:		An ultrastructural study on the pancreatic islet B cells in diabetic herbivorous voles
Author(s):		Sasaki M; Arai T; Oki Y; Komeda K;
Address:		"Development Research Laboratories, Banyu Pharmaceutical Co. Ltd., Saitama, Japan"
Journal Title:		Vet Res Commun
Year:		1991
Volume:		15
Issue:		3
Page Number:		205 - 210
DOI:		10.1007/BF00343225
ISSN/ISBN:		0165-7380 (Print) 0165-7380 (Linking)
Abstract:		"An ultrastructural study was performed on the pancreatic islet cells of normal herbivorous voles and of voles in which diet-induced diabetes had been induced by feeding a low-fibre, high-concentrate diet. Examination of the pancreatic islet cells revealed degranulation and a well-developed Golgi apparatus and rough endoplasmic reticulum in the B cells of the slightly diabetic voles showing moderate hyperglycaemia and hyperinsulinaemia, and markedly degenerative B cells with almost complete absence of secretory granules in the severely diabetic voles showing marked hyperglycaemia and hypoinsulinaemia. These results indicate that the pancreatic B cells had become hyperfunctional so that insulin secretion was increased in the slightly diabetic voles; thereafter the B cells degenerated rapidly and the voles fell into insulin deficiency"
Keywords:		"Animals *Arvicolinae Cell Degranulation Diabetes Mellitus, Experimental/*pathology Endoplasmic Reticulum/ultrastructure Female Golgi Apparatus/ultrastructure Insulin/blood Islets of Langerhans/*ultrastructure Male Rodent Diseases/*pathology;"
Notes:		"MedlineSasaki, M Arai, T Oki, Y Komeda, K eng Switzerland 1991/01/01 Vet Res Commun. 1991; 15(3):205-10. doi: 10.1007/BF00343225"