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J Hazard Mater

Title:		"Oral bioaccessibility of semi-volatile organic compounds (SVOCs) in settled dust: A review of measurement methods, data and influencing factors"
Author(s):		Raffy G; Mercier F; Glorennec P; Mandin C; Le Bot B;
Address:		"Univ Rennes, Inserm, EHESP, Irset (Institut de recherche en sante, environnement et travail) - UMR_S 1085, F 35000, Rennes, France. Electronic address: gaelle.raffy@ehesp.fr. Univ Rennes, Inserm, EHESP, Irset (Institut de recherche en sante, environnement et travail) - UMR_S 1085, F 35000, Rennes, France. Universite Paris Est, CSTB - Scientific and Technical Center for Building, OQAI - French Indoor Air Quality Observatory, 84 Avenue Jean Jaures Champs-sur-Marne 77447 Marne-la-Vallee Cedex 2, France"
Journal Title:		J Hazard Mater
Year:		2018
Volume:		20180321
Issue:
Page Number:		215 - 227
DOI:		10.1016/j.jhazmat.2018.03.035
ISSN/ISBN:		1873-3336 (Electronic) 0304-3894 (Linking)
Abstract:		"Many semi-volatile organic compounds (SVOCs), suspected of reprotoxic, neurotoxic or carcinogenic effects, were measured in indoor settled dust. Dust ingestion is a non-negligible pathway of exposure to some of these SVOCs, and an accurate knowledge of the real exposure is necessary for a better evaluation of health risks. To this end, the bioaccessibility of SVOCs in dust needs to be considered. In the present work, bioaccessibility measurement methods, SVOCs' oral bioaccessibility data and influencing factors were reviewed. SVOC bioaccessibilities (%) ranged from 11 to 94, 8 to 100, 3 to 92, 1 to 81, 6 to 52, and 2 to 17, for brominated flame retardants, organophosphorus flame retardants, polychlorobiphenyls, phthalates, pesticides and polycyclic aromatic hydrocarbons, respectively. Measurements method produced varying results depending on the inclusion of food and/or sink in the model. Characteristics of dust, e.g., organic matter content and particle size, also influenced bioaccessibility data. Last, results were influenced by SVOC properties, such as octanol/water partition coefficient and migration pathway into dust. Factors related to dust and SVOCs could be used in prediction models. To this end, more bioaccessibility studies covering more substances should be performed, using methods that are harmonized and validated by comparison to in-vivo studies"
Keywords:		"Air Pollution, Indoor/*analysis Biological Availability Dust/*analysis Eating Environmental Monitoring/methods Food Contamination/*analysis Humans Volatile Organic Compounds/*analysis Bioavailability Dust ingestion Human exposure Indoor environment Pollut;"
Notes:		"MedlineRaffy, Gaelle Mercier, Fabien Glorennec, Philippe Mandin, Corinne Le Bot, Barbara eng Review Netherlands 2018/04/06 J Hazard Mater. 2018 Jun 15; 352:215-227. doi: 10.1016/j.jhazmat.2018.03.035. Epub 2018 Mar 21"