| Title: | Portable comprehensive two-dimensional micro-gas chromatography using an integrated flow-restricted pneumatic modulator |
| Author(s): | Huang X; Li MW; Zang W; Huang X; Sivakumar AD; Sharma R; Fan X; |
| Address: | "Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109 USA. GRID: grid.214458.e. ISNI: 0000000086837370 Department of Electrical Engineering and Computer Science, University of Michigan, Ann Arbor, MI 48109 USA. GRID: grid.214458.e. ISNI: 0000000086837370 Center for Wireless Integrated MicroSensing and Systems (WIMS2), University of Michigan, Ann Arbor, MI 48109 USA. GRID: grid.214458.e. ISNI: 0000000086837370 Max Harry Weil Institute for Critical Care Research and InnovationUniversity of Michigan, Ann Arbor, MI 48109 USA. GRID: grid.214458.e. ISNI: 0000000086837370" |
| DOI: | 10.1038/s41378-022-00452-5 |
| ISSN/ISBN: | 2055-7434 (Electronic) 2096-1030 (Print) 2055-7434 (Linking) |
| Abstract: | "Two-dimensional (2D) gas chromatography (GC) provides enhanced vapor separation capabilities in contrast to conventional one-dimensional GC and is useful for the analysis of highly complex chemical samples. We developed a microfabricated flow-restricted pneumatic modulator (FRPM) for portable comprehensive 2D micro-GC (muGC), which enables rapid (2)D injection and separation without compromising the (1)D separation speed and eluent peak profiles. (2)D injection characteristics such as injection peak width and peak height were fully characterized by using flow-through micro-photoionization detectors (muPIDs) at the FRPM inlet and outlet. A (2)D injection peak width of ~25 ms could be achieved with a (2)D/(1)D flow rate ratio over 10. The FRPM was further integrated with a 0.5-m long (2)D mucolumn on the same chip, and its performance was characterized. Finally, we developed an automated portable comprehensive 2D muGC consisting of a 10 m OV-1 (1)D mucolumn, an integrated FRPM with a built-in 0.5 m polyethylene glycol (2)D mucolumn, and two muPIDs. Rapid separation of 40 volatile organic compounds in ~5 min was demonstrated. A hybrid 2D contour plot was constructed by using both (1)D and (2)D chromatograms obtained with the two muPIDs at the end of the (1)D and (2)D mucolumns, which was enabled by the presence of the flow resistor in the FRPM" |
| Keywords: | Chemistry Electrical and electronic engineering; |
| Notes: | "PubMed-not-MEDLINEHuang, Xiaheng Li, Maxwell Wei-Hao Zang, Wenzhe Huang, Xiaolu Sivakumar, Anjali Devi Sharma, Ruchi Fan, Xudong eng England 2022/11/05 Microsyst Nanoeng. 2022 Nov 1; 8:115. doi: 10.1038/s41378-022-00452-5. eCollection 2022" |
