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Genes Dev

Title:		The rate of cell growth is governed by cell cycle stage
Author(s):		Goranov AI; Cook M; Ricicova M; Ben-Ari G; Gonzalez C; Hansen C; Tyers M; Amon A;
Address:		"David H. Koch Institute for Integrative Cancer Research and Howard Hughes Medical Institute, Massachusetts Institute of Technology, E17-233, Cambridge, Massachusetts 02139, USA"
Journal Title:		Genes Dev
Year:		2009
Volume:		23
Issue:		12
Page Number:		1408 - 1422
DOI:		10.1101/gad.1777309
ISSN/ISBN:		1549-5477 (Electronic) 0890-9369 (Print) 0890-9369 (Linking)
Abstract:		"Cell growth is an essential requirement for cell cycle progression. While it is often held that growth is independent of cell cycle position, this relationship has not been closely scrutinized. Here we show that in budding yeast, the ability of cells to grow changes during the cell cycle. We find that cell growth is faster in cells arrested in anaphase and G1 than in other cell cycle stages. We demonstrate that the establishment of a polarized actin cytoskeleton-either as a consequence of normal cell division or through activation of the mating pheromone response-potently attenuates protein synthesis and growth. We furthermore show by population and single-cell analysis that growth varies during an unperturbed cell cycle, slowing at the time of polarized growth. Our study uncovers a fundamental relationship whereby cell cycle position regulates growth"
Keywords:		Actins/metabolism Cell Cycle/drug effects/genetics/*physiology Cell Cycle Proteins/genetics Cell Enlargement/drug effects Cell Size Down-Regulation/drug effects Mutation/genetics Pheromones/pharmacology Saccharomyces cerevisiae/*cytology/drug effects/grow;
Notes:		"MedlineGoranov, Alexi I Cook, Michael Ricicova, Marketa Ben-Ari, Giora Gonzalez, Christian Hansen, Carl Tyers, Mike Amon, Angelika eng HHMI/Howard Hughes Medical Institute/ R29 GM056800/GM/NIGMS NIH HHS/ R01 GM056800/GM/NIGMS NIH HHS/ WT_/Wellcome Trust/United Kingdom GM056800/GM/NIGMS NIH HHS/ Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't 2009/06/17 Genes Dev. 2009 Jun 15; 23(12):1408-22. doi: 10.1101/gad.1777309"