| Title: | Functional genomics of dietary restriction and longevity in yeast |
| Address: | "Unidad de Genomica Avanzada (Langebio), Centro de Investigacion y de Estudios Avanzados del IPN, 36824, Irapuato, Guanajuato, Mexico. Electronic address: sergio.e.campos@cinvestav.mx. Unidad de Genomica Avanzada (Langebio), Centro de Investigacion y de Estudios Avanzados del IPN, 36824, Irapuato, Guanajuato, Mexico. Electronic address: alexander.deluna@cinvestav.mx" |
| DOI: | 10.1016/j.mad.2019.02.003 |
| ISSN/ISBN: | 1872-6216 (Electronic) 0047-6374 (Linking) |
| Abstract: | "Dietary restriction-limitation of calories or other specific nutrients in the diet-is the sole non-genetic intervention known to extend the lifespan of a wide range of model organisms from yeast to mammals. Cell biology studies on the responses to dietary restriction have provided important clues about the mechanisms of longevity; however, a comprehensive genome-wide description of lifespan by dietary restriction has been mostly absent. Large-scale genetic analysis in the budding yeast Saccharomyces cerevisiae offers a great opportunity to uncover the conserved systems-level mechanisms that give way to longevity in response to diet. Here, we review recent advances in high-throughput phenotyping of the replicative and chronological life spans of yeast cells, which have contributed to our understanding of longevity by dietary restriction and the cellular crosstalks of nutrient-sensing regulation" |
| Keywords: | "Cell Cycle DNA Replication Gene Deletion Genes, Fungal Genome-Wide Association Study Genomics/*methods Phenotype Pheromones/metabolism Saccharomyces cerevisiae/genetics/*metabolism/*physiology Signal Transduction Aging mechanisms Dietary restriction Genom;" |
| Notes: | "MedlineCampos, Sergio E DeLuna, Alexander eng Research Support, Non-U.S. Gov't Review Ireland 2019/02/23 Mech Ageing Dev. 2019 Apr; 179:36-43. doi: 10.1016/j.mad.2019.02.003. Epub 2019 Feb 18" |
