| Title: | "Using the blood concentration of 2,5-dimethylfuran as a marker for smoking" |
| Author(s): | Ashley DL; Bonin MA; Hamar B; McGeehin M; |
| Address: | "Division of Environmental Health Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA 30341-3724, USA" |
| Journal Title: | Int Arch Occup Environ Health |
| ISSN/ISBN: | 0340-0131 (Print) 0340-0131 (Linking) |
| Abstract: | "Correct analysis of whole blood volatile organic compounds (VOCs) in evaluating possible exposure situations requires differentiation of smokers from nonsmokers. Whole blood concentrations of 2,5-dimethylfuran are determined using an internal standard method, and the concentrations of this compound are evaluated as a marker for smoking in exposure-study subjects. Results indicate that the concentration of 2,5-dimethylfuran can be adequately determined in whole blood by a method already in use for determining VOCs in blood. The whole blood concentration of 2,5-dimethylfuran was an excellent predictor of smoking when compared with positive responses about smoking on questionnaires. Using a detection limit of 0.024 ppb, 2,5-dimethylfuran concentrations in blood correctly identified the smoking status of 96.4% of the subjects in this study. The blood 2,5-dimethylfuran concentration was linearly related to the number of cigarettes smoked per day. This method is advantageous since blood 2,5-dimethylfuran concentrations can be determined using the same method used to determine concentrations of other VOCs, thus obviating the need for additional analytical procedures" |
| Keywords: | Biomarkers/analysis/*blood Female Furans/analysis/*blood Hazardous Substances/*adverse effects Humans Male Reference Values Sensitivity and Specificity *Smoking Surveys and Questionnaires; |
| Notes: | "MedlineAshley, D L Bonin, M A Hamar, B McGeehin, M eng Comparative Study Germany 1996/01/01 Int Arch Occup Environ Health. 1996; 68(3):183-7. doi: 10.1007/BF00381629" |
