« Previous Abstract[Phenomenon of group and genital activity in the rat]    Next Abstract"Volatile emissions of scented Alstroemeria genotypes are dominated by terpenes, and a myrcene synthase gene is highly expressed in scented Alstroemeria flowers" »

J Cell Biol

Title:		Pheromone-encoding mRNA is transported to the yeast mating projection by specific RNP granules
Author(s):		Aronov S; Dover-Biterman S; Suss-Toby E; Shmoish M; Duek L; Choder M;
Address:		"Department of Molecular Microbiology, Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa 31096, Israel Department of Molecular Biology, Ariel University, Ariel 40700, Israel stellar@ariel.ac.il. Department of Molecular Microbiology, Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa 31096, Israel. Multidisciplinary Laboratory, Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa 31096, Israel. Multidisciplinary Laboratory, Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa 31096, Israel Bioinformatics Knowledge Unit, The Lorry I. Lokey Interdisciplinary Center for Life Sciences and Engineering, Technion-Israel Institute of Technology, Haifa 31096, Israel"
Journal Title:		J Cell Biol
Year:		2015
Volume:		209
Issue:		6
Page Number:		829 - 842
DOI:		10.1083/jcb.201408045
ISSN/ISBN:		1540-8140 (Electronic) 0021-9525 (Print) 0021-9525 (Linking)
Abstract:		"Association of messenger RNAs with large complexes such as processing bodies (PBs) plays a pivotal role in regulating their translation and decay. Little is known about other possible functions of these assemblies. Exposure of haploid yeast cells, carrying mating type 'a,' to 'alpha pheromone' stimulates polarized growth resulting in a 'shmoo' projection; it also induces synthesis of 'a pheromone,' encoded by MFA2. In this paper, we show that, in response to alpha pheromone, MFA2 mRNA is assembled with two types of granules; both contain some canonical PB proteins, yet they differ in size, localization, motility, and sensitivity to cycloheximide. Remarkably, one type is involved in mRNA transport to the tip of the shmoo, whereas the other-in local translation in the shmoo. Normal assembly of these granules is critical for their movement, localization, and for mating. Thus, MFA2 mRNAs are transported to the shmoo tip, in complex with PB-like particles, where they are locally translated"
Keywords:		"Biological Transport Cell Membrane Structures/metabolism Cell Surface Extensions/*metabolism Cytoplasmic Granules/genetics/metabolism Lipoproteins/*biosynthesis/genetics Pheromones/*biosynthesis/genetics RNA, Messenger/*metabolism Ribonucleoproteins/*meta;"
Notes:		"MedlineAronov, Stella Dover-Biterman, Saray Suss-Toby, Edith Shmoish, Michael Duek, Lea Choder, Mordechai eng Research Support, Non-U.S. Gov't 2015/06/24 J Cell Biol. 2015 Jun 22; 209(6):829-42. doi: 10.1083/jcb.201408045"