« Previous Abstract"Diversity, abundance, and sex-specific expression of chemosensory proteins in the reproductive organs of the locust Locusta migratoria manilensis"    Next AbstractAir toxic emissions from snowmobiles in Yellowstone National Park »

J Biol Chem

Title:		Identification of MUP1 as a regulator for glucose and lipid metabolism in mice
Author(s):		Zhou Y; Jiang L; Rui L;
Address:		"Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, Michigan 48109-0622, USA"
Journal Title:		J Biol Chem
Year:		2009
Volume:		20090303
Issue:		17
Page Number:		11152 - 11159
DOI:		10.1074/jbc.M900754200
ISSN/ISBN:		0021-9258 (Print) 1083-351X (Electronic) 0021-9258 (Linking)
Abstract:		"Major urinary protein (MUP) 1 is a lipocalin family member abundantly secreted into the circulation by the liver. MUP1 binds to lipophilic pheromones and is excreted in urine. Urinary MUP1/pheromone complexes mediate chemical communication in rodents. However, it is unclear whether circulatory MUP1 has additional physiological functions. Here we show that MUP1 regulates glucose and lipid metabolism. MUP1 expression was markedly reduced in both genetic and dietary fat-induced obesity and diabetes. Mice were infected with MUP1 adenoviruses via tail vein injection, and recombinant MUP1 was overexpressed in the liver and secreted into the bloodstream. Recombinant MUP1 markedly attenuated hyperglycemia and glucose intolerance in genetic (db/db) and dietary fat-induced type 2 diabetic mice as well as in streptozotocin-induced type 1 diabetic mice. MUP1 inhibited the expression of both gluconeogenic genes and lipogenic genes in the liver. Moreover, recombinant MUP1 directly decreased glucose production in primary hepatocyte cultures by inhibiting the expression of gluconeogenic genes. These data suggest that MUP1 regulates systemic glucose and/or lipid metabolism through the paracrine/autocrine regulation of the hepatic gluconeogenic and/or lipogenic programs, respectively"
Keywords:		"Adenoviridae/metabolism Animals Diabetes Mellitus, Type 2/metabolism *Gene Expression Regulation Gluconeogenesis Glucose/*metabolism Glucose Tolerance Test Glycogen/metabolism Hepatocytes/metabolism *Lipid Metabolism Mice Mice, Inbred C57BL Proteins/metab;"
Notes:		"MedlineZhou, Yingjiang Jiang, Lin Rui, Liangyou eng P30 CA046592/CA/NCI NIH HHS/ R01 DK073601/DK/NIDDK NIH HHS/ R01 DK 065122/DK/NIDDK NIH HHS/ 5P60 DK20572/DK/NIDDK NIH HHS/ R01 DK065122/DK/NIDDK NIH HHS/ 5 P30 CA46592/CA/NCI NIH HHS/ DK34933/DK/NIDDK NIH HHS/ P60 DK020572/DK/NIDDK NIH HHS/ P30 DK034933/DK/NIDDK NIH HHS/ Research Support, N.I.H., Extramural 2009/03/05 J Biol Chem. 2009 Apr 24; 284(17):11152-9. doi: 10.1074/jbc.M900754200. Epub 2009 Mar 3"