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Environ Res
| Title: | Associations between residential volatile organic compound exposures and liver injury markers: The role of biological sex and race |
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| Author(s): | Wahlang B; Gao H; Rai SN; Keith RJ; McClain CJ; Srivastava S; Cave MC; Bhatnagar A; |
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| Address: | "Superfund Research Center, University of Louisville, Louisville, KY, 40202, USA; Division of Gastroenterology, Hepatology & Nutrition, Department of Medicine, School of Medicine, University of Louisville, Louisville, KY, 40202, USA; The Center for Integrative Environmental Health Sciences, University of Louisville, Louisville, KY, 40202, USA; The Hepatobiology and Toxicology Center, University of Louisville, Louisville, KY, 40202, USA. Electronic address: banrida.wahlang@louisville.edu. Superfund Research Center, University of Louisville, Louisville, KY, 40202, USA; Envirome Institute, University of Louisville, Louisville, KY, 40202, USA; Division of Environmental Medicine, Department of Medicine, School of Medicine, University of Louisville, Louisville, KY, 40202, USA. Division of Biostatistics and Bioinformatics, Department of Environmental and Public Health Sciences, College of Medicine, University of Cincinnati, Cincinnati, OH, 45267, USA; Cancer Data Science Center, Biostatistics and Informatics Shared Resource, College of Medicine, University of Cincinnati, Cincinnati, OH, 45267, USA. Superfund Research Center, University of Louisville, Louisville, KY, 40202, USA; Division of Gastroenterology, Hepatology & Nutrition, Department of Medicine, School of Medicine, University of Louisville, Louisville, KY, 40202, USA; The Center for Integrative Environmental Health Sciences, University of Louisville, Louisville, KY, 40202, USA; Department of Pharmacology & Toxicology, School of Medicine, University of Louisville, Louisville, KY, 40202, USA; The Hepatobiology and Toxicology Center, University of Louisville, Louisville, KY, 40202, USA; Alcohol Research Center, University of Louisville, Louisville, KY, 40202, USA. Superfund Research Center, University of Louisville, Louisville, KY, 40202, USA; Envirome Institute, University of Louisville, Louisville, KY, 40202, USA; Division of Environmental Medicine, Department of Medicine, School of Medicine, University of Louisville, Louisville, KY, 40202, USA; Department of Pharmacology & Toxicology, School of Medicine, University of Louisville, Louisville, KY, 40202, USA; Department of Biochemistry and Molecular Genetics, School of Medicine, University of Louisville, Louisville, KY, 40202, USA. Superfund Research Center, University of Louisville, Louisville, KY, 40202, USA; Division of Gastroenterology, Hepatology & Nutrition, Department of Medicine, School of Medicine, University of Louisville, Louisville, KY, 40202, USA; The Center for Integrative Environmental Health Sciences, University of Louisville, Louisville, KY, 40202, USA; Department of Pharmacology & Toxicology, School of Medicine, University of Louisville, Louisville, KY, 40202, USA; The Hepatobiology and Toxicology Center, University of Louisville, Louisville, KY, 40202, USA; Alcohol Research Center, University of Louisville, Louisville, KY, 40202, USA; Department of Biochemistry and Molecular Genetics, School of Medicine, University of Louisville, Louisville, KY, 40202, USA. Superfund Research Center, University of Louisville, Louisville, KY, 40202, USA; The Center for Integrative Environmental Health Sciences, University of Louisville, Louisville, KY, 40202, USA; Envirome Institute, University of Louisville, Louisville, KY, 40202, USA; Division of Environmental Medicine, Department of Medicine, School of Medicine, University of Louisville, Louisville, KY, 40202, USA; Department of Pharmacology & Toxicology, School of Medicine, University of Louisville, Louisville, KY, 40202, USA; Department of Biochemistry and Molecular Genetics, School of Medicine, University of Louisville, Louisville, KY, 40202, USA" |
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| Journal Title: | Environ Res |
| Year: | 2023 |
| Volume: | 20230104 |
| Issue: | |
| Page Number: | 115228 - |
| DOI: | 10.1016/j.envres.2023.115228 |
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| ISSN/ISBN: | 1096-0953 (Electronic) 0013-9351 (Print) 0013-9351 (Linking) |
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| Abstract: | "While occupational exposures to volatile organic compounds (VOCs) have been linked to steatohepatitis and liver cancer in industrial workers, recent findings have also positively correlated low-dose, residential VOC exposures with liver injury markers. VOC sources are numerous; factors including biological make up (sex), socio-cultural constructs (gender, race) and lifestyle (smoking) can influence both VOC exposure levels and disease outcomes. Therefore, the current study's objective is to investigate how sex and race influence associations between residential VOC exposures and liver injury markers particularly in smokers vs. nonsmokers. Subjects (n = 663) were recruited from residential neighborhoods; informed consent was obtained. Exposure biomarkers included 16 urinary VOC metabolites. Serological disease biomarkers included liver enzymes, direct bilirubin, and hepatocyte death markers (cytokeratin K18). Pearson correlations and generalized linear models were conducted. Models were adjusted for common liver-related confounders and interaction terms. The study population constituted approximately 60% females (n = 401) and 40% males (n = 262), and a higher percent of males were smokers and/or frequent drinkers. Both sexes had a higher percent of White (75% females, 82% males) vs. Black individuals. Positive associations were identified for metabolites of acrolein, acrylamide, acrylonitrile, butadiene, crotonaldehyde, and styrene with alkaline phosphatase (ALP), a biomarker for cholestatic injury; and for the benzene metabolite with bilirubin; only in females. These associations were retained in female smokers. Similar associations were also observed between these metabolites and ALP only in White individuals (n = 514). In Black individuals (n = 114), the styrene metabolite was positively associated with aspartate transaminase. Interaction models indicated that positive associations for acrylamide/crotonaldehyde metabolites with ALP in females were dose-dependent. Most VOC associations with K18 markers were negative in this residential population. Overall, the findings demonstrated that biological sex, race, and smoking status influence VOC effects on liver injury and underscored the role of biological-social-lifestyle factor(s) interactions when addressing air pollution-related health disparities" |
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| Keywords: | Male Humans Female *Volatile Organic Compounds/analysis *Air Pollutants/analysis Liver/chemistry Biomarkers/urine Acrylamides Styrenes Alp Liver injury Race Residential Sex differences VOCs; |
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| Notes: | "MedlineWahlang, Banrida Gao, Hong Rai, Shesh N Keith, Rachel J McClain, Craig J Srivastava, Sanjay Cave, Mathew C Bhatnagar, Aruni eng P30 ES030283/ES/NIEHS NIH HHS/ P50 AA024337/AA/NIAAA NIH HHS/ U54 HL120163/HL/NHLBI NIH HHS/ R01 ES029846/ES/NIEHS NIH HHS/ K01 ES033289/ES/NIEHS NIH HHS/ P20 GM113226/GM/NIGMS NIH HHS/ R35 ES028373/ES/NIEHS NIH HHS/ P42 ES023716/ES/NIEHS NIH HHS/ Research Support, N.I.H., Extramural Netherlands 2023/01/08 Environ Res. 2023 Mar 15; 221:115228. doi: 10.1016/j.envres.2023.115228. Epub 2023 Jan 4" |
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