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J Asthma

Title:		Fragrance materials in asthma: a pilot study using a surrogate aerosol product
Author(s):		Vethanayagam D; Vliagoftis H; Mah D; Beach J; Smith L; Moqbel R;
Address:		"Department of Medicine, University of Alberta , Edmonton, Alberta , Canada"
Journal Title:		J Asthma
Year:		2013
Volume:		20130820
Issue:		9
Page Number:		975 - 982
DOI:		10.3109/02770903.2013.822079
ISSN/ISBN:		1532-4303 (Electronic) 0277-0903 (Linking)
Abstract:		"OBJECTIVE: Many household products contain fragrances. Little is known about exposure to fragrances on human health, particularly within the airways. This study aimed to evaluate how common household fragrance products (i.e. air fresheners, cleaning products) affect people with asthma, who frequently report sensitivity to these products. Many of these products have volatile organic compounds or semi-volatile organic compounds. This study evaluated nine fragrance materials in an aerosol formulation to assess effects on airway physiology, airway inflammation and symptom perception in normal controls and those with asthma. METHODS: The effects of fragrances were evaluated in people without asthma, people with mild asthma and people with moderate asthma in a four-way crossover placebo-controlled study. Subjects were exposed twice to a fragranced aerosol and twice to a placebo aerosol (15 and 30 min each). Subjects completed a questionnaire for 29 symptoms during and up to 3 h after each exposure scenario. Spirometry was performed prior to and 3 h post-exposure; sputum induction was conducted 3 h post-exposure. RESULTS: Nasal symptoms showed the greatest frequency of response in all three subject groups, and moderate asthmatics reported the greatest symptom severity and symptom types. No significant differences were noted in physiology or cellular inflammation. CONCLUSION: A trend for increased symptoms was noted in moderate asthmatics, suggesting that asthma severity may play a factor in fragrance sensitivity"
Keywords:		"Adolescent Adult Aerosols/adverse effects Aged Asthma/*immunology Cross-Over Studies Female Household Products/*adverse effects Humans Inflammation/*immunology Male Middle Aged Perfume/adverse effects Pilot Projects Spirometry Statistics, Nonparametric Su;"
Notes:		"MedlineVethanayagam, Dilini Vliagoftis, Harissios Mah, Dennell Beach, Jeremy Smith, Ladd Moqbel, Redwan eng Randomized Controlled Trial Research Support, Non-U.S. Gov't England 2013/07/09 J Asthma. 2013 Nov; 50(9):975-82. doi: 10.3109/02770903.2013.822079. Epub 2013 Aug 20"