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Gen Comp Endocrinol

Title:		"The biosynthesis of steroid glucuronides in the testis of the zebrafish, Brachydanio rerio, and their pheromonal function as ovulation inducers"
Author(s):		van den Hurk R; Schoonen WG; van Zoelen GA; Lambert JG;
Address:		"Department of Experimental Zoology, University of Utrecht, The Netherlands"
Journal Title:		Gen Comp Endocrinol
Year:		1987
Volume:		68
Issue:		2
Page Number:		179 - 188
DOI:		10.1016/0016-6480(87)90027-x
ISSN/ISBN:		0016-6480 (Print) 0016-6480 (Linking)
Abstract:		"In female zebrafish ovulation could be induced by male holding water, testis homogenates, and testis fractions containing steroid glucuronides. Deglucuronidation of these fractions led to a loss of ovulation-inducing potency, indicating steroid glucuronides as ovulation inducers. The chemical substances were perceived by the recipient females by means of olfaction. Incubation experiments showed the capacity of the testes to synthesize various C19 and C21 steroids and seven different steroid glucuronides, i.e., 17 alpha, 20 beta-dihydroxy-4-pregnen-3-one-, testosterone-, androsterone-, epiandrosterone-, 5 alpha-androstane-3 alpha, 17 beta-diol-, and 5 alpha-androstane-3 beta, 17 beta-diol glucuronide. GC-MS analysis showed the presence of glucuronides of 5 alpha-androstane-3 alpha, 17 beta-diol and cholesterol in male holding water, the latter probably originating from the liver. These compounds may be among the steroid glucuronides functioning as ovulation-inducing pheromones"
Keywords:		"Androstenedione/pharmacology Animals Chromatography, Thin Layer Female Gonadal Steroid Hormones/*biosynthesis In Vitro Techniques Male *Ovulation *Pheromones Pregnenolone/pharmacology Progestins/*biosynthesis Testis/drug effects/*metabolism Water/analysis;"
Notes:		"Medlinevan den Hurk, R Schoonen, W G van Zoelen, G A Lambert, J G eng 1987/11/01 Gen Comp Endocrinol. 1987 Nov; 68(2):179-88. doi: 10.1016/0016-6480(87)90027-x"