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Curr Opin Insect Sci

Title:		Cytochromes P450: terpene detoxification and pheromone production in bark beetles
Author(s):		Blomquist GJ; Tittiger C; MacLean M; Keeling CI;
Address:		"Biochemistry and Molecular Biology, University of Nevada, Reno, NV, United States. Electronic address: garyb@cabnr.unr.edu. Biochemistry and Molecular Biology, University of Nevada, Reno, NV, United States. Laurentian Forestry Centre, Canadian Forest Service, Natural Resources Canada, Quebec, QC, Canada; Departement de biochimie, de microbiologie et de bio-informatique, Universite Laval, Quebec, QC, Canada"
Journal Title:		Curr Opin Insect Sci
Year:		2021
Volume:		20201221
Issue:
Page Number:		97 - 102
DOI:		10.1016/j.cois.2020.11.010
ISSN/ISBN:		2214-5753 (Electronic)
Abstract:		"Bark beetles (family: Curculionidae; subfamily: Scolytinae) in the Dendroctonus and Ips genera are the most destructive forest pests in the Northern hemisphere. They use cytochromes P450 (P450s) to detoxify tree-produced terpenes to produce pheromones, in de novo pheromone production and to oxidize odorants on antennae. Many Dendroctonus spp. use trans-verbenol as an aggregation pheromone, and it is formed from host-tree produced alpha-pinene hydroxylated by CYP6DE1 during larval stages, stored as verbenyl ester of fatty acids, and then released when the female begins feeding on a new host tree. Ips spp. hydroxylate de novo produced myrcene to form ipsdienol. Subsequent steps form the appropriate enantiomeric composition of ipsdienol and convert ipsdienol to ipsenol. In this article we review recent progress in elucidating the functions of P450s in Ips and Dendroctonus species and in doing so provide insights into the role of these enzymes in host phytochemical detoxification and pheromone production"
Keywords:		"Alcohols/metabolism Animals Bicyclic Monoterpenes/metabolism *Cytochrome P-450 Enzyme System *Inactivation, Metabolic Pheromones Terpenes/metabolism Tracheophyta/chemistry Weevils/*enzymology/*metabolism;"
Notes:		"MedlineBlomquist, Gary J Tittiger, Claus MacLean, Marina Keeling, Christopher I eng Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Review Netherlands 2020/12/29 Curr Opin Insect Sci. 2021 Feb; 43:97-102. doi: 10.1016/j.cois.2020.11.010. Epub 2020 Dec 21"