| Title: | "Characterization of Metal-Bound Benzimidazole Derivatives, Effects on Tumor Cells of Lung Cancer" |
| Author(s): | Raducka A; Czylkowska A; Gobis K; Czarnecka K; Szymanski P; Swiatkowski M; |
| Address: | "Institute of General and Ecological Chemistry, Faculty of Chemistry, Lodz University of Technology, Zeromskiego 116, 90-924 Lodz, Poland. Department of Organic Chemistry, Faculty of Pharmacy, Medical University of Gdansk, Gen. Hallera 107, 80-416 Gdansk, Poland. Department of Pharmaceutical Chemistry, Drug Analyses and Radiopharmacy, Faculty of Pharmacy, Medical University of Lodz, Muszynskiego 1, 90-151 Lodz, Poland. Department of Radiobiology and Radiation Protection, Military Institute of Hygiene and Epidemiology, 4 Kozielska St., 01-163 Warsaw, Poland" |
| ISSN/ISBN: | 1996-1944 (Print) 1996-1944 (Electronic) 1996-1944 (Linking) |
| Abstract: | "Four new ligands and four new copper (II) coordination compounds were prepared and characterized by chemical, elemental analysis, cytotoxicity, and FTIR spectroscopy (Fourier transform infrared spectroscopy). The nature of metal-ligand coordination was investigated. The thermal properties of complexes in the solid state were studied using TG-MS techniques (thermogravimetric analysis coupled with mass spectrometry) under dynamic flowing air atmosphere to analyze the principal volatile thermal decomposition and fragmentation products that evolved during thermolysis. The intermediate and final solid thermolysis products were also determined. The MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazoliumbromide) assay was used to evaluate active metabolic cells as an IC(50) (half maximal inhibitory concentration). The relationship between antitumor activity and the position of nitrogen atoms in the organic ligand has been shown" |
| Keywords: | benzimidazole derivatives copper (II) coordination compounds lung cancer thermogravimetric analysis; |
| Notes: | "PubMed-not-MEDLINERaducka, Anita Czylkowska, Agnieszka Gobis, Katarzyna Czarnecka, Kamila Szymanski, Pawel Swiatkowski, Marcin eng Switzerland 2021/06/03 Materials (Basel). 2021 May 30; 14(11):2958. doi: 10.3390/ma14112958" |
