| Title: | The Effect of Ethnicity on Human Axillary Odorant Production |
| Author(s): | Prokop-Prigge KA; Greene K; Varallo L; Wysocki CJ; Preti G; |
| Address: | "Monell Chemical Senses Center, 3500 Market Street, Philadelphia, PA, 19104, USA. kprigge@monell.org. Monell Chemical Senses Center, 3500 Market Street, Philadelphia, PA, 19104, USA. School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA. Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA" |
| DOI: | 10.1007/s10886-015-0657-8 |
| ISSN/ISBN: | 1573-1561 (Electronic) 0098-0331 (Print) 0098-0331 (Linking) |
| Abstract: | "Previous findings from our laboratory highlighted marked ethnic differences in volatile organic compounds (VOCs) from cerumen among individuals of Caucasian, East Asian, and African-American descent, based, in part, on genetic differences in a gene that codes for a transport protein, which is a member of the ATP-binding cassette transporter, sub-family C, member 11 (ABCC11). In the current work, we hypothesized that axillary odorants produced by East Asians would differ markedly from those obtained from individuals of European or African descent based on the pattern of ethnic diversity that exists in ABCC11. Using gas chromatography/mass spectrometry (GC/MS) we examined differences in axillary odorant VOCs among 30 individuals of African-American, Caucasian, and East Asian descent with respect to their ABCC11 genotype. While no qualitative differences in the type of axillary odorants were observed across ethnic groups, we found that characteristic axillary odorants varied quantitatively with respect to ethnic origin. We propose that ABCC11 is not solely responsible for predicting the relative amounts of volatiles found in axillary secretions and that other biochemical pathways must be involved" |
| Keywords: | ATP-Binding Cassette Transporters/genetics Adult Asian People/genetics Black People/genetics Cerumen/chemistry/metabolism *Gas Chromatography-Mass Spectrometry Genotype Humans Male Odorants/*analysis Volatile Organic Compounds/*analysis/chemistry White Pe; |
| Notes: | "MedlineProkop-Prigge, Katharine A Greene, Kathryn Varallo, Lauren Wysocki, Charles J Preti, George eng P30 DC011735/DC/NIDCD NIH HHS/ T32 DC000014/DC/NIDCD NIH HHS/ 5T32DC0014/DC/NIDCD NIH HHS/ P30DC01173/DC/NIDCD NIH HHS/ Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't 2015/12/05 J Chem Ecol. 2016 Jan; 42(1):33-9. doi: 10.1007/s10886-015-0657-8. Epub 2015 Dec 3" |
