| Title: | Detection of Barrett's oesophagus through exhaled breath using an electronic nose device |
| Author(s): | Peters Y; Schrauwen RWM; Tan AC; Bogers SK; de Jong B; Siersema PD; |
| Address: | "Gastroenterology and Hepatology, Radboudumc, Nijmegen, Gelderland, The Netherlands. Gastroenterology and Hepatology, Ziekenhuis Bernhoven, Uden, Noord-Brabant, The Netherlands. Canisius Wilhelmina Hospital, Nijmegen, The Netherlands. Gastroenterology and Hepatology, Radboudumc, Nijmegen, Gelderland, The Netherlands peter.siersema@radboudumc.nl" |
| DOI: | 10.1136/gutjnl-2019-320273 |
| ISSN/ISBN: | 1468-3288 (Electronic) 0017-5749 (Linking) |
| Abstract: | "Timely detection of oesophageal adenocarcinoma (OAC) and even more so its precursor Barrett's oesophagus (BO) could contribute to decrease OAC incidence and mortality. An accurate, minimally-invasive screening method for BO for widespread use is currently not available. In a proof-of-principle study in 402 patients, we developed and cross-validated a BO prediction model using volatile organic compounds (VOCs) analysis with an electronic nose device. This electronic nose was able to distinguish between patients with and without BO with good diagnostic accuracy (sensitivity 91% specificity 74%) and seemed to be independent of proton pump inhibitor use, the presence of hiatal hernia, and reflux. This technique may enable an efficient, well-tolerated, and sensitive and specific screening method to select high-risk individuals to undergo upper endoscopy" |
| Keywords: | Barrett Esophagus/*diagnosis Breath Tests/instrumentation/*methods Case-Control Studies *Electronic Nose Female Humans Male Middle Aged Reproducibility of Results Sensitivity and Specificity Volatile Organic Compounds/analysis barrett's oesophagus breath; |
| Notes: | "MedlinePeters, Yonne Schrauwen, Ruud W M Tan, Adriaan C Bogers, Sanne K de Jong, Bart Siersema, Peter D eng England 2020/02/27 Gut. 2020 Jul; 69(7):1169-1172. doi: 10.1136/gutjnl-2019-320273. Epub 2020 Feb 25" |
