| Title: | Activation of GABA(A) receptors in the accessory olfactory bulb does not prevent the formation of an olfactory memory in mice |
| Author(s): | Otsuka T; Hashida M; Oka T; Kaba H; |
| Address: | "Department of Veterinary Physiology, Faculty of Agriculture, Kagoshima University, Japan" |
| ISSN/ISBN: | 0916-7250 (Print) 0916-7250 (Linking) |
| Abstract: | "When female mice are mated, they form a memory to the pheromonal signal of their male partner. The neural mechanisms underlying this memory involve changes at the reciprocal dendrodendritic synapses between glutamatergic mitral cells and gamma-aminobutyric acid (GABA)-ergic granule cells in the accessory olfactory bulb (AOB). Blockade of GABA(A) receptors in the AOB leads to the formation of an olfactory memory. In an attempt to disrupt memory formation at mating, we used local infusions of the GABA(A) receptor agonist muscimol into the AOB during the critical period for memory formation. Muscimol across a wide range of doses (1-1000 pmol) did not prevent memory formation. The resistance of this memory to GABA(A) receptor activation may reflect the complexity of synaptic microcircuits in the AOB" |
| Keywords: | "Animals Female GABA Agonists/pharmacology Male Memory/drug effects/*physiology Mice Mice, Inbred BALB C Mice, Inbred CBA Muscimol/pharmacology Olfactory Bulb/drug effects/*physiology Pregnancy Receptors, GABA-A/drug effects/*physiology Sex Attractants/phy;" |
| Notes: | "MedlineOtsuka, T Hashida, M Oka, T Kaba, H eng Research Support, Non-U.S. Gov't Japan 2001/08/16 J Vet Med Sci. 2001 Jul; 63(7):807-9. doi: 10.1292/jvms.63.807" |
