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Sci Total Environ

Title:		Associations between prenatal exposure to volatile organic compounds and neurodevelopment in 12-month-old children: The Japan Environment and Children's Study (JECS)
Author(s):		Nakaoka H; Hisada A; Matsuzawa D; Yamamoto M; Mori C; Japan E; Children's Study G; Kamijima M; Yamazaki S; Ohya Y; Kishi R; Yaegashi N; Hashimoto K; Mori C; Ito S; Yamagata Z; Inadera H; Nakayama T; Iso H; Shima M; Kurozawa Y; Suganuma N; Kusuhara K; Katoh T;
Address:		"Centre for Preventive Medical Sciences, Chiba University, Japan; Department of Bioenvironmental Medicine, Graduate School of Medicine, Chiba University, Japan. Electronic address: hnakaoka@faculty.chiba-u.jp. Centre for Preventive Medical Sciences, Chiba University, Japan. Research Center for Child Mental Development, Chiba University, Japan. Centre for Preventive Medical Sciences, Chiba University, Japan; Department of Bioenvironmental Medicine, Graduate School of Medicine, Chiba University, Japan. Nagoya City University, Nagoya, Japan. National Institute for Environmental Studies, Tsukuba, Japan. National Center for Child Health and Development, Tokyo, Japan. Hokkaido University, Sapporo, Japan. Tohoku University, Sendai, Japan. Fukushima Medical University, Fukushima, Japan. Chiba University, Chiba, Japan. Yokohama City University, Yokohama, Japan. University of Yamanashi, Chuo, Japan. University of Toyama, Toyama, Japan. Kyoto University, Kyoto, Japan. Osaka University, Suita, Japan. Hyogo College of Medicine, Nishinomiya, Japan. Tottori University, Yonago, Japan. Kochi University, Nankoku, Japan. University of Occupational and Environmental Health, Kitakyushu, Japan. Kumamoto University, Kumamoto, Japan"
Journal Title:		Sci Total Environ
Year:		2021
Volume:		20210624
Issue:
Page Number:		148643 -
DOI:		10.1016/j.scitotenv.2021.148643
ISSN/ISBN:		1879-1026 (Electronic) 0048-9697 (Linking)
Abstract:		"In recent years, there has been an increase in the number of problems associated with neurodevelopmental disorders in children, and there has been a growing interest in the relationship between environmental chemicals and children's health. The objective of this study was to examine whether an association exists between occupational or environmental prenatal maternal exposure to volatile organic compounds and the risk of neurodevelopmental disorders in children using Japanese translations of the Ages & Stages Questionnaires, Third Edition (J-ASQ-3). An increase in the risk of neurodevelopmental delay in 12-month-old children associated with maternal exposure to formalin or formaldehyde was identified in terms of problem-solving (odds ratio (OR): 1.76, 95% confidence interval (CI): 0.99-3.12) and personal-social skills (OR: 3.32, 95% CI: 1.46-7.55). It is not clear whether or not this tendency is reversible, and whether it is observed past 12 months of age. Further research and a preventive approach are needed"
Keywords:		Child Cohort Studies Female Humans Infant Japan Maternal Exposure/adverse effects Pregnancy *Prenatal Exposure Delayed Effects/chemically induced/epidemiology *Volatile Organic Compounds/toxicity Ages & Stages questionnaire Cohort study Formalin/formaldeh;
Notes:		"MedlineNakaoka, Hiroko Hisada, Aya Matsuzawa, Daisuke Yamamoto, Midori Mori, Chisato (JECS) Kamijima, Michihiro Yamazaki, Shin Ohya, Yukihiro Kishi, Reiko Yaegashi, Nobuo Hashimoto, Koichi Ito, Shuichi Yamagata, Zentaro Inadera, Hidekuni Nakayama, Takeo Iso, Hiroyasu Shima, Masayuki Kurozawa, Youichi Suganuma, Narufumi Kusuhara, Koichi Katoh, Takahiko eng Netherlands 2021/07/02 Sci Total Environ. 2021 Nov 10; 794:148643. doi: 10.1016/j.scitotenv.2021.148643. Epub 2021 Jun 24"