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J Chromatogr B Biomed Sci Appl

Title:		Modelling alterations in the partition coefficient in in vitro biological systems using headspace gas chromatography
Author(s):		McIntosh JM; Heffron JJ;
Address:		"Department of Biochemistry, National University of Ireland, Cork. scbi6036@bureau.ucc.ie"
Journal Title:		J Chromatogr B Biomed Sci Appl
Year:		2000
Volume:		738
Issue:		2
Page Number:		207 - 216
DOI:		10.1016/s0378-4347(99)00506-x
ISSN/ISBN:		1387-2273 (Print) 1387-2273 (Linking)
Abstract:		"Headspace gas chromatography was used to determine the physiological media-air partition coefficient (K) of four volatile organic solvents of industrial importance. The experimental conditions were those likely to be used in in vitro metabolic and toxicological studies on volatile compounds. The addition of solvent to the liquid phase from a stock solution in ethanol, or the presence of organic material at concentrations normally seen in in vitro studies, did not significantly alter the K value. Binary solvent addition resulted in a dose-dependent decrease in K for each solvent that was also influenced by the solvent solubility and the constituents of the liquid matrix. The aromatic solvents exerted the greatest effect and showed the greatest change in K value"
Keywords:		"Chromatography, Gas/*methods Models, Chemical Solvents;"
Notes:		"MedlineMcIntosh, J M Heffron, J J eng Research Support, Non-U.S. Gov't Netherlands 2000/03/16 J Chromatogr B Biomed Sci Appl. 2000 Feb 11; 738(2):207-16. doi: 10.1016/s0378-4347(99)00506-x"