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Indoor Air

Title:		Health effects of exposure to indoor volatile organic compounds from 1980 to 2017: A systematic review and meta-analysis
Author(s):		Liu N; Bu Z; Liu W; Kan H; Zhao Z; Deng F; Huang C; Zhao B; Zeng X; Sun Y; Qian H; Mo J; Sun C; Guo J; Zheng X; Weschler LB; Zhang Y;
Address:		"Department of Building Science, Tsinghua University, Beijing, China. Beijing Key Laboratory of Indoor Air Quality Evaluation and Control, Beijing, China. Department of Energy and Environmental System Engineering, Zhejiang University of Science and Technology, Hangzhou, China. Institute for Health and Environment, Chongqing University of Science and Technology, Chongqing, China. School of Public Health, Fudan University, Shanghai, China. School of Public Health, Peking University, Beijing, China. School of Environment and Architecture, University of Shanghai for Science and Technology, Shanghai, China. School of Environment and Natural Resources, Renmin University of China, Beijing, China. School of Environmental Science and Engineering, Tianjin University, Tianjin, China. School of Energy and Environment, Southeast University, Nanjing, China. Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China. Colts Neck, New Jersey, USA"
Journal Title:		Indoor Air
Year:		2022
Volume:		32
Issue:		5
Page Number:		e13038 -
DOI:		10.1111/ina.13038
ISSN/ISBN:		1600-0668 (Electronic) 0905-6947 (Linking)
Abstract:		"Exposure to volatile organic compounds (VOCs) indoors is thought to be associated with several adverse health effects. However, we still lack concentration-response (C-R) relationships between VOC levels in civil buildings and various health outcomes. For this paper, we conducted a systematic review and meta-analysis of observational studies to summarize related associations and C-R relationships. Four databases were searched to collect all relevant studies published between January 1980 and December 2017. A total of 39 studies were identified in the systematic review, and 32 of these were included in the meta-analysis. We found that the pooled relative risk (RR) for leukemia was 1.03 (95% CI: 1.01-1.05) per 1 mug/m(3) increase of benzene and 1.25 (95%CI: 1.14-1.37) per 0.1 mug/m(3) increase of butadiene. The pooled RRs for asthma were 1.08 (95% CI: 1.02-1.14), 1.02 (95% CI: 1.00-1.04), and 1.04 (95% CI: 1.02-1.06) per 1 mug/m(3) increase of benzene, toluene, and p-dichlorobenzene, respectively. The pooled RR for low birth weight was 1.12 (95% CI: 1.05-1.19) per 1 mug/m(3) increase of benzene. Our findings provide robust evidence for associations between benzene and leukemia, asthma, and low birth weight, as well as for health effects of some other VOCs"
Keywords:		"*Air Pollutants/analysis *Air Pollution, Indoor/adverse effects/analysis *Asthma Benzene/analysis Humans *Leukemia/epidemiology/etiology Observational Studies as Topic *Volatile Organic Compounds/analysis asthma civil building health outcome leukemia meta;"
Notes:		"MedlineLiu, Ningrui Bu, Zhongming Liu, Wei Kan, Haidong Zhao, Zhuohui Deng, Furong Huang, Chen Zhao, Bin Zeng, Xiangang Sun, Yuexia Qian, Hua Mo, Jinhan Sun, Chanjuan Guo, Jianguo Zheng, Xiaohong Weschler, Louise B Zhang, Yinping eng Meta-Analysis Research Support, Non-U.S. Gov't Review Systematic Review England 2022/05/28 Indoor Air. 2022 May; 32(5):e13038. doi: 10.1111/ina.13038"