| Title: | "The combination of dissimilar alleles of the A alpha and A beta gene complexes, whose proteins contain homeo domain motifs, determines sexual development in the mushroom Coprinus cinereus" |
| Author(s): | Kues U; Richardson WV; Tymon AM; Mutasa ES; Gottgens B; Gaubatz S; Gregoriades A; Casselton LA; |
| Address: | "School of Biological Sciences, Queen Mary and Westfield College, London, UK" |
| ISSN/ISBN: | 0890-9369 (Print) 0890-9369 (Linking) |
| Abstract: | "The A mating-type factor is one of two gene complexes that allows mating cells of the mushroom Coprinus cinereus to recognize self from nonself and to regulate a pathway of sexual development that leads to meiosis and sporulation. We have identified seven A genes separated into two subcomplexes corresponding to the classical A alpha and A beta loci. Four genes, one alpha and three beta, all coding for proteins with a homeo domain-related motif, determine A-factor specificity; their allelic forms are so different in sequence that they do not cross-hybridize. It requires only one of these four genes to be heteroallelic in a cell to trigger A-regulated sexual development, and it is the different combinations of their alleles that generate the multiple A factors found in nature. The other three genes cause no change in cell morphology and may regulate the activity of the four specificity genes" |
| Keywords: | "Alleles Amino Acid Sequence Autoradiography Base Sequence Basidiomycota/*genetics/physiology DNA, Fungal/genetics *Genes, Homeobox Mating Factor Molecular Sequence Data Nucleic Acid Hybridization Peptides/genetics Plasmids Restriction Mapping Saccharomyce;" |
| Notes: | "MedlineKues, U Richardson, W V Tymon, A M Mutasa, E S Gottgens, B Gaubatz, S Gregoriades, A Casselton, L A eng Research Support, Non-U.S. Gov't 1992/04/01 Genes Dev. 1992 Apr; 6(4):568-77. doi: 10.1101/gad.6.4.568" |
