| Title: | "Evaluation of the odour of Aminoleban(R) EN, taste-masked with flavoured powders, by human and electronic noses" |
| Author(s): | Haraguchi T; Yoshida M; Uchida T; |
| Address: | "School of Pharmaceutical Sciences, Mukogawa Women's University, Nishinomiya City, Japan" |
| ISSN/ISBN: | 2042-7158 (Electronic) 0022-3573 (Linking) |
| Abstract: | "OBJECTIVES: Aminoleban(R) EN is a bitter total enteral nutrient product with an unpleasant odour. The purpose of this study was to evaluate the odour of Aminoleban(R) EN, taste-masked with various flavoured powders, by human testing and by using an electronic nose system (Alpha M.O.S.). METHODS: Initially, the odour of Aminoleban(R) EN alone at various concentrations was evaluated. Secondly, the odour of Aminoleban(R) EN with the addition of various flavoured powders was evaluated; the evaluation included data on odour intensity, preference levels and evoked taste image. KEY FINDINGS: With the human nose, a concentration of 0.43 g/100 ml seemed to be the taste threshold for Aminoleban(R) EN. In the electronic nose system, principal component analysis revealed that concentrations over 0.39 g/100 ml Aminoleban(R) EN could be distinguished from water. It was clear from both human testing and using the electronic nose system that the unpleasant odour of Aminoleban(R) EN could be masked by pineapple- and plum-flavoured powders, both of which contain not only sweet but also sour components. CONCLUSIONS: The electronic nose system may be useful for detecting odours at or below the level detectable by the human olfactory system and for classifying the quality of different odours, thus reducing the amount of human testing required" |
| Keywords: | "Adult Amino Acids, Branched-Chain/adverse effects/analysis Electronic Nose Enteral Nutrition Female Flavoring Agents/*chemistry/pharmacology Food Preferences Food, Formulated/*adverse effects/analysis Humans Japan Limit of Detection *Odorants Powders Prin;" |
| Notes: | "MedlineHaraguchi, Tamami Yoshida, Miyako Uchida, Takahiro eng Comparative Study Research Support, Non-U.S. Gov't England 2013/03/16 J Pharm Pharmacol. 2013 Apr; 65(4):503-11. doi: 10.1111/jphp.12009. Epub 2012 Nov 22" |
