| Title: | Gastrointestinal Interaction between Dietary Amino Acids and Gut Microbiota: With Special Emphasis on Host Nutrition |
| Author(s): | Abdallah A; Elemba E; Zhong Q; Sun Z; |
| Address: | "Key laboratory of Straw Biology and Utilization (The Ministry of Education), Key Lab of Animal Nutrition and Feed Science, Key Lab of Animal Production, Product Quality and Security, College of Animal Science and Technology, Jilin Agricultural University, Changchun, China College of Food Science and Engineering, Jilin Agricultural University, Changchun, Jilin 130118, China" |
| DOI: | 10.2174/1389203721666200212095503 |
| ISSN/ISBN: | 1875-5550 (Electronic) 1389-2037 (Linking) |
| Abstract: | "The gastrointestinal tract (GIT) of humans and animals is host to a complex community of different microorganisms whose activities significantly influence host nutrition and health through enhanced metabolic capabilities, protection against pathogens, and regulation of the gastrointestinal development and immune system. New molecular technologies and concepts have revealed distinct interactions between the gut microbiota and dietary amino acids (AAs) especially in relation to AA metabolism and utilization in resident bacteria in the digestive tract, and these interactions may play significant roles in host nutrition and health as well as the efficiency of dietary AA supplementation. After the protein is digested and AAs and peptides are absorbed in the small intestine, significant levels of endogenous and exogenous nitrogenous compounds enter the large intestine through the ileocaecal junction. Once they move in the colonic lumen, these compounds are not markedly absorbed by the large intestinal mucosa, but undergo intense proteolysis by colonic microbiota leading to the release of peptides and AAs and result in the production of numerous bacterial metabolites such as ammonia, amines, short-chain fatty acids (SCFAs), branched-chain fatty acids (BCFAs), hydrogen sulfide, organic acids, and phenols. These metabolites influence various signaling pathways in epithelial cells, regulate the mucosal immune system in the host, and modulate gene expression of bacteria which results in the synthesis of enzymes associated with AA metabolism. This review aims to summarize the current literature relating to how the interactions between dietary amino acids and gut microbiota may promote host nutrition and health" |
| Keywords: | Amino Acids/*metabolism Ammonia/metabolism Animal Feed/analysis/microbiology Animals Biological Transport/physiology Carboxylic Acids/metabolism Carrier Proteins/classification/genetics/metabolism Dietary Proteins/administration & dosage/*metabolism Fatty; |
| Notes: | "MedlineAbdallah, Abedin Elemba, Evera Zhong, Qingzhen Sun, Zewei eng Review United Arab Emirates 2020/02/13 Curr Protein Pept Sci. 2020; 21(8):785-798. doi: 10.2174/1389203721666200212095503" |
