| Title: | Microwave-assisted deuterium exchange: the convenient preparation of isotopically labelled analogues for stable isotope dilution analysis of volatile wine phenols |
| Author(s): | Crump AM; Sefton MA; Wilkinson KL; |
| Address: | "The University of Adelaide, School of Agriculture, Food and Wine, PMB 1, Glen Osmond, SA 5064, Australia. The University of Adelaide, School of Agriculture, Food and Wine, PMB 1, Glen Osmond, SA 5064, Australia. Electronic address: kerry.wilkinson@adelaide.edu.au" |
| DOI: | 10.1016/j.foodchem.2014.04.051 |
| ISSN/ISBN: | 1873-7072 (Electronic) 0308-8146 (Linking) |
| Abstract: | "This study reports the convenient, low cost, one-step synthesis of labelled analogues of six volatile phenols, guaiacol, 4-methylguaiacol, 4-ethylguaiacol, 4-ethylphenol, eugenol and vanillin, using microwave-assisted deuterium exchange, for use as internal standards for stable isotope dilution analysis. The current method improves on previous strategies in that it enables incorporation of deuterium atoms on the aromatic ring, thereby ensuring retention of the isotope label during mass spectrometry fragmentation. When used as standards for SIDA, these labelled volatile phenols will improve the accuracy and reproducibility of quantitative food and beverage analysis" |
| Keywords: | Benzaldehydes Cresols *Deuterium Eugenol Guaiacol/analogs & derivatives Indicator Dilution Techniques Isotope Labeling/*methods Mass Spectrometry/methods *Microwaves Phenols/*analysis Reproducibility of Results Volatile Organic Compounds/*analysis Wine/*a; |
| Notes: | "MedlineCrump, Anna M Sefton, Mark A Wilkinson, Kerry L eng Research Support, Non-U.S. Gov't England 2014/05/31 Food Chem. 2014 Nov 1; 162:261-3. doi: 10.1016/j.foodchem.2014.04.051. Epub 2014 Apr 24" |
