| Title: | The Candida albicans agglutinin-like sequence family of adhesins: functional insights gained from structural analysis |
| Address: | "Department of Life Sciences, Imperial College London, SW7 2AZ, London, UK. Department of Pathobiology, University of Illinois at Urbana-Champaign, Urbana, IL 61802, USA" |
| ISSN/ISBN: | 1746-0921 (Electronic) 1746-0913 (Linking) |
| Abstract: | "Candida albicans colonizes many host sites suggesting its interaction with diverse ligands. Candida albicans adhesion is mediated by a number of proteins including those in the Als (agglutinin-like sequence) family, which have been studied intensively. The recent solution of the Als binding domain structure ended years of speculation regarding the molecular mechanism for Als adhesive function. Als adhesins bind flexible C termini from a broad collection of proteins, providing the basis for adhesion to various cell types and perhaps for C. albicans broad tissue tropism. Understanding adhesive functions at the molecular level will reveal the sequence of events in C. albicans pathogenesis, from host recognition to complex interactions such as development of polymicrobial biofilms or disseminated disease" |
| Keywords: | "Amino Acid Sequence Antigens, Fungal/*chemistry/genetics Candida albicans/genetics/*pathogenicity Candidiasis/pathology Cell Adhesion/*physiology Fungal Proteins/*chemistry/genetics Humans Mating Factor Molecular Sequence Data Peptides/*metabolism Nmr adh;" |
| Notes: | "MedlineCota, Ernesto Hoyer, Lois L eng BB/K003887/1/Biotechnology and Biological Sciences Research Council/United Kingdom R01 DE14158/DE/NIDCR NIH HHS/ Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review England 2015/10/07 Future Microbiol. 2015; 10(10):1635-548. doi: 10.2217/fmb.15.79. Epub 2015 Oct 6" |
