« Previous AbstractUltrasensitive Surface-Enhanced Raman Scattering Sensor of Gaseous Aldehydes as Biomarkers of Lung Cancer on Dendritic Ag Nanocrystals    Next AbstractTwo highly related odorant receptors specifically detect alpha-bile acid pheromones in sea lamprey (Petromyzon marinus) »

Front Neural Circuits

Title:		Whole-Brain Mapping of the Inputs and Outputs of the Medial Part of the Olfactory Tubercle
Author(s):		Zhang Z; Zhang H; Wen P; Zhu X; Wang L; Liu Q; Wang J; He X; Wang H; Xu F;
Address:		"College of Life Science and Technology, Huazhong University of Science and TechnologyWuhan, China. Center for Brain Science, Key Laboratory of Magnetic Resonance in Biological Systems and State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, Wuhan Institute of Physics and Mathematics, CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of SciencesWuhan, China. Wuhan National Laboratory for OptoelectronicsWuhan, China. College of Life Sciences, Wuhan UniversityWuhan, China. Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of SciencesShanghai, China"
Journal Title:		Front Neural Circuits
Year:		2017
Volume:		20170728
Issue:
Page Number:		52 -
DOI:		10.3389/fncir.2017.00052
ISSN/ISBN:		1662-5110 (Electronic) 1662-5110 (Linking)
Abstract:		"The medial part of the olfactory tubercle (OT) is a brain structure located at the interface of the reward and olfactory system. It is closely related to pheromone-rewards, natural reinforcement, addiction and many other behaviors. However, the structure of the anatomic circuitry of the medial part of the OT is still unclear. In the present study, the medial part of the OT was found to be highly connected with a wide range of brain areas with the help of the pseudorabies virus tracing tool. In order to further investigate the detailed connections for specific neurons, another tracing tool - rabies virus was utilized for D1R-cre and D2R-cre mice. The D1R and D2R neurons in the medial part of the OT were both preferentially innervated by the olfactory areas, especially the piriform cortex, and both had similar direct input patterns. With the help of the adeno-associated virus labeling, it was found that the two subpopulations of neurons primarily innervate with the reward related brain regions, with slightly less axons projecting to the olfactory areas. Thus, the whole-brain input and output circuitry structures for specific types of neurons in the medial part of the OT were systematically investigated, and the results revealed many unique connecting features. This work could provide new insights for further study into the physiological functions of the medial part of the OT"
Keywords:		"Animals Male Mice, Inbred C57BL Mice, Transgenic Microscopy, Confocal Neuroanatomical Tract-Tracing Techniques Neurons/*cytology/metabolism Olfactory Pathways/cytology/metabolism Olfactory Tubercle/*cytology/metabolism Receptors, Dopamine D1/genetics/meta;"
Notes:		"MedlineZhang, Zhijian Zhang, Hongruo Wen, Pengjie Zhu, Xutao Wang, Li Liu, Qing Wang, Jie He, Xiaobin Wang, Huadong Xu, Fuqiang eng Switzerland 2017/08/15 Front Neural Circuits. 2017 Jul 28; 11:52. doi: 10.3389/fncir.2017.00052. eCollection 2017"