| Title: | Exposure to dim light at night prior to conception attenuates offspring innate immune responses |
| Author(s): | Cisse YM; Russart K; Nelson RJ; |
| Address: | "Department of Pharmacology, University of Maryland School of Medicine, Baltimore, Maryland, United States of America. Department of Neuroscience, The Ohio State University Wexner Medical Center, Columbus, Ohio, United States of America. Department of Neuroscience, Rockefeller Neuroscience Institute, West Virginia University, Morgantown, West Virginia, United States of America" |
| DOI: | 10.1371/journal.pone.0231140 |
| ISSN/ISBN: | 1932-6203 (Electronic) 1932-6203 (Linking) |
| Abstract: | "Functional circadian timekeeping is necessary for homeostatic control of the immune system and appropriate immune responsiveness. Disruption of natural light-dark cycles, through light at night (LAN), impairs innate and adaptive immune responses in nocturnal rodents. These altered immune responses are associated with disrupted endogenous gene transcriptional and endocrine cycles. However, few studies have addressed the multigenerational consequences of systemic circadian rhythm disruption. We hypothesized that parental exposure to dim LAN (dLAN) would alter innate immune and sickness responses to an endotoxin challenge in adult offspring gestated and reared in dark nights. Adult male and female Siberian hamsters were exposed to either dark nights (DARK) or dLAN (~5 lux) for 8 weeks, then paired, mated, and thereafter housed under dark nights. Maternal exposure to dLAN prior to conception impaired febrile responses and increased splenic il-1 production in response to LPS in male offspring. Paternal pre-conception dLAN dampened offspring tnf-alpha expression in the hypothalamus, reduced serum bactericidal capacity, and dark phase locomotor activity. These changes occurred despite offspring being conceived, gestated, and reared under standard dark night conditions. Overall, these data suggest that dLAN has intergenerational effects on innate immunity and sickness responses" |
| Keywords: | "Animals Animals, Newborn Circadian Rhythm/*immunology/radiation effects Female Immunity, Innate/*radiation effects Light/*adverse effects Male Maternal Exposure/*adverse effects Models, Animal Paternal Exposure/*adverse effects Phodopus Photoperiod;neuroscience;" |
| Notes: | "MedlineCisse, Yasmine M Russart, Kathryn Nelson, Randy J eng F32 HD101302/HD/NICHD NIH HHS/ Research Support, N.I.H., Extramural Research Support, U.S. Gov't, Non-P.H.S. 2020/04/18 PLoS One. 2020 Apr 17; 15(4):e0231140. doi: 10.1371/journal.pone.0231140. eCollection 2020" |
