| Title: | Volatolomics analysis of exhaled breath and gastric-endoluminal gas for distinguishing early upper gastrointestinal cancer from benign |
| Author(s): | Xiang C; Yang H; Zhao Z; Deng F; Lv Y; Yang Y; Duan Y; Li W; Hu B; |
| Address: | "School of Chemistry, Sichuan University, Chengdu 610065, People's Republic of China. Department of Gastroenterology, West China Hospital, Sichuan University, Chengdu 610064, People's Republic of China. School of Mechanical Engineering, Sichuan University, Chengdu 610064, People's Republic of China. School of Chemical Engineering, Sichuan University, Chengdu 610064, People's Republic of China. Aliben Sci & Technol Co Ltd, Chengdu 611930, People's Republic of China. West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu 610064, People's Republic of China" |
| ISSN/ISBN: | 1752-7163 (Electronic) 1752-7155 (Linking) |
| Abstract: | "Exhaled breath and gastric-endoluminal gas (volatile products of diseased tissues) contain a large number of volatile organic compounds, which are valuable for early diagnosis of upper gastrointestinal (UGI) cancer. In this study, exhaled breath and gastric-endoluminal gas of patients with UGI cancer and benign disease were analyzed by gas chromatography-mass spectrometry (GC-MS) and ultraviolet photoionization time-of-flight mass spectrometry (UVP-TOFMS) to construct UGI cancer diagnostic models. Breath samples of 116 UGI cancer and 77 benign disease subjects and gastric-endoluminal gas samples of 114 UGI cancer and 76 benign disease subjects were collected. Machine learning (ML) algorithms were used to construct UGI cancer diagnostic models. Classification models based on exhaled breath for distinguishing UGI cancer from the benign group have area under the curve (AUC) of receiver operating characteristic curve values of 0.959 and 0.994 corresponding to GC-MS and UVP-TOFMS analysis, respectively. The AUC values of models based on gastric-endoluminal gas for UGI cancer and benign group classification are 0.935 and 0.929 corresponding to GC-MS and UVP-TOFMS analysis, respectively. This work indicates that volatolomics analysis of exhaled breath and gastric-endoluminal diseased tissues have great potential in early screening of UGI cancer. Moreover, gastric-endoluminal gas can be a means of gas biopsy to provide auxiliary information for the examination of tissue lesions during gastroscopy" |
| Keywords: | Humans Breath Tests/methods Gas Chromatography-Mass Spectrometry/methods Mass Spectrometry *Volatile Organic Compounds/analysis *Lung Neoplasms/diagnosis Exhalation biomarkers cancer diagnosis exhaled breath gastric-endoluminal gas upper gastrointestinal; |
| Notes: | "MedlineXiang, Chengfang Yang, Hang Zhao, Zhongjun Deng, Fulong Lv, Yantong Yang, Yanting Duan, Yixiang Li, Wenwen Hu, Bing eng Research Support, Non-U.S. Gov't England 2023/04/25 J Breath Res. 2023 May 3; 17(3). doi: 10.1088/1752-7163/accfb8" |
