| Title: | Long-term indoor air conditioner filtration and cardiovascular health: A randomized crossover intervention study |
| Author(s): | Chuang HC; Ho KF; Lin LY; Chang TY; Hong GB; Ma CM; Liu IJ; Chuang KJ; |
| Address: | "School of Respiratory Therapy, College of Medicine, Taipei Medical University, Taipei, Taiwan; Division of Pulmonary Medicine, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan; Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan. The Jockey Club School of Public Health and Primary Care, The Chinese University of Hong Kong, Hong Kong, China; Key Laboratory of Aerosol Chemistry and Physics, SKLLQG, Institute of Earth Environment, Chinese Academy of Sciences, Xian, 710075, China; Shenzhen Municipal Key Laboratory for Health Risk Analysis, Shenzhen Research Institute of the Chinese University of Hong Kong, Shenzhen, China. Division of Cardiology, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan. Department of Occupational Safety and Health, College of Public Health, China Medical University, Taichung, Taiwan. Department of Chemical Engineering and Biotechnology, National Taipei University of Technology, Taipei, Taiwan. Department of Cosmetic Application and Management, Saint Mary's Junior College of Medicine, Nursing and Management, Yilan County, Taiwan. Department of Nursing, Cardinal Tien College of Healthcare & Management, New Taipei City, Taiwan. Department of Public Health, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan. Electronic address: kjc@tmu.edu.tw" |
| DOI: | 10.1016/j.envint.2017.06.008 |
| ISSN/ISBN: | 1873-6750 (Electronic) 0160-4120 (Linking) |
| Abstract: | "The association of short-term air pollution filtration with cardiovascular health has been documented. However, the effect of long-term indoor air conditioner filtration on the association between air pollution and cardiovascular health is still unclear. We recruited 200 homemakers from Taipei and randomly assigned 100 of them to air filtration or control intervention; six home visits were conducted per year from 2013 to 2014. The participants under air filtration intervention during 2013 were reassigned to control intervention in 2014. The air pollution measurements consisted of particulate matter less than or equal to 2.5mum in diameter (PM(2.5)) and total volatile organic compounds (VOCs); blood pressure was monitored for each participant during each visit. The following morning, blood samples were collected after air pollution monitoring. The blood samples were used to analyze biological markers, including high sensitivity-C-reactive protein (hs-CRP), 8-hydroxy-2'-deoxyguanosine (8-OHdG) and fibrinogen. Household information, including cleaning, cooking, and air conditioning, was collected by a questionnaire. Mixed-effects models were used to investigate the associations among air pollution measurements, blood pressure and biological markers. The results showed that increased levels of PM(2.5) and total VOCs were associated with increased hs-CRP, 8-OHdG and blood pressure. The health variables were higher among participants in the control intervention phase than among those in the air filtration intervention phase. We concluded that air pollution exposure was associated with systemic inflammation, oxidative stress and elevated blood pressure. The long-term filtration of air pollution with an air conditioner filter was associated with cardiovascular health of adults" |
| Keywords: | "8-Hydroxy-2'-Deoxyguanosine Adult Aged *Air Conditioning Air Pollutants/adverse effects/analysis *Air Pollution, Indoor/adverse effects/analysis/prevention & control Biomarkers/blood C-Reactive Protein/analysis Cross-Over Studies Deoxyguanosine/analogs &;" |
| Notes: | "MedlineChuang, Hsiao-Chi Ho, Kin-Fai Lin, Lian-Yu Chang, Ta-Yuan Hong, Gui-Bing Ma, Chi-Ming Liu, I-Jung Chuang, Kai-Jen eng Randomized Controlled Trial Netherlands 2017/06/19 Environ Int. 2017 Sep; 106:91-96. doi: 10.1016/j.envint.2017.06.008. Epub 2017 Jun 15" |
