| Title: | Prediction of mortality in severe acute malnutrition in hospitalized children by faecal volatile organic compound analysis: proof of concept |
| Author(s): | van den Brink DA; de Meij T; Brals D; Bandsma RHJ; Thitiri J; Ngari M; Mwalekwa L; de Boer NKH; Wicaksono A; Covington JA; van Rheenen PF; Voskuijl WP; |
| Address: | "Department of Paediatrics, Centre for Liver, Digestive and Metabolic Diseases, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands. d.a.vandenbrink@amsterdamumc.nl. Amsterdam Centre for Global Child Health, Emma Children's Hospital, Amsterdam University Medical Centres, Amsterdam, The Netherlands. d.a.vandenbrink@amsterdamumc.nl. Department of Paediatric Gastroenterology, Emma, Children's Hospital, Amsterdam University Medical Centres, Amsterdam, The Netherlands. Amsterdam Centre for Global Child Health, Emma Children's Hospital, Amsterdam University Medical Centres, Amsterdam, The Netherlands. Department of Global Health, Amsterdam Institute for Global Health and Development, Amsterdam University Medical Centres, Amsterdam, The Netherlands. Department of Paediatrics, Centre for Liver, Digestive and Metabolic Diseases, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands. Division of Gastroenterology, Hepatology and Nutrition and Translational Medicine Program, Hospital for Sick Children, Toronto, Canada. The Childhood Acute Illness & Nutrition Network (CHAIN), Nairobi, Kenya. Department of Biomedical Sciences, College of Medicine, University of Malawi, Blantyre, Malawi. KEMRI/Welcome Trust Research Programme, Kilifi, Kenya. Department of Gastroenterology and Hepatology, Amsterdam Gastroenterology and Metabolism Research Institute, Amsterdam University Medical Centres, Amsterdam, The Netherlands. School of Engineering, University of Warwick, Coventry, UK. Amsterdam Centre for Global Child Health, Emma Children's Hospital, Amsterdam University Medical Centres, Amsterdam, The Netherlands. w.p.voskuijl@amsterdamumc.nl. Department of Global Health, Amsterdam Institute for Global Health and Development, Amsterdam University Medical Centres, Amsterdam, The Netherlands. w.p.voskuijl@amsterdamumc.nl. The Childhood Acute Illness & Nutrition Network (CHAIN), Nairobi, Kenya. w.p.voskuijl@amsterdamumc.nl. Department of Paediatrics, College of Medicine, University of Malawi, Blantyre, Malawi. w.p.voskuijl@amsterdamumc.nl" |
| DOI: | 10.1038/s41598-020-75515-6 |
| ISSN/ISBN: | 2045-2322 (Electronic) 2045-2322 (Linking) |
| Abstract: | "Children with severe acute malnutrition (SAM) display immature, altered gut microbiota and have a high mortality risk. Faecal volatile organic compounds (VOCs) reflect the microbiota composition and may provide insight into metabolic dysfunction that occurs in SAM. Here we determine whether analysis of faecal VOCs could identify children with SAM with increased risk of mortality. VOC profiles from children who died within six days following admission were compared to those who were discharged alive using machine learning algorithms. VOC profiles of children who died could be separated from those who were discharged with fair accuracy (AUC) = 0.71; 95% CI 0.59-0.87; P = 0.004). We present the first study showing differences in faecal VOC profiles between children with SAM who survived and those who died. VOC analysis holds potential to help discover metabolic pathways within the intestinal microbiome with causal association with mortality and target treatments in children with SAM.Trial Registration: The F75 study is registered at clinicaltrials.gov/ct2/show/NCT02246296" |
| Keywords: | "Acute Disease Case-Control Studies Child Child, Preschool Feces/*chemistry Female Gastrointestinal Microbiome *Hospitalization Humans *Inpatients Male Proof of Concept Study Severity of Illness Index Volatile Organic Compounds/*analysis;" |
| Notes: | "Medlinevan den Brink, Deborah A de Meij, Tim Brals, Daniella Bandsma, Robert H J Thitiri, Johnstone Ngari, Moses Mwalekwa, Laura de Boer, Nanne K H Wicaksono, Alfian Covington, James A van Rheenen, Patrick F Voskuijl, Wieger P eng Research Support, Non-U.S. Gov't England 2020/11/07 Sci Rep. 2020 Nov 5; 10(1):18785. doi: 10.1038/s41598-020-75515-6" |
