| Title: | Telemetric monitoring of penile pressure during mating in rats after chronic spinal cord injury |
| Author(s): | Steadman CJ; Vangoor SS; Hubscher CH; |
| Address: | "Anatomical Sciences and Neurobiology, University of Louisville, Louisville, Kentucky. Kentucky Spinal Cord Injury Research Center, Louisville, Kentucky" |
| Journal Title: | Am J Physiol Regul Integr Comp Physiol |
| DOI: | 10.1152/ajpregu.00171.2019 |
| ISSN/ISBN: | 1522-1490 (Electronic) 0363-6119 (Linking) |
| Abstract: | "In men with a spinal cord injury (SCI), erectile function, ejaculation, and fertility are severely impaired. The present study utilized a telemetric pressure transducer implanted into the corpus cavernosum of the penis to examine sexual function during awake mating behavior in a rat contusion model with a range of Infinite Horizon Impactor forces distributed between 150 and 215 kdyn. The mating behavior paradigm included examination of the counts, average pressure, and average duration for mounts, intromissions, and ejaculations. Male Wistar rats were mated with receptive females in 30-min sessions preinjury (sexual acclimation) and once per week for 6 wk beginning after a 2-wk recovery period post-SCI. All SCI animals had significant deficits in sexual function in the parameters measured. These deficiencies were more prevalent in a subset having less than 20% white matter sparing, likely a reflection of the extent of bilateral spino-bulbo-spinal sexual circuitry disruption at the lesion epicenter. The resulting discoordination of the autonomic and somatic reflex control of erection and ejaculation recorded using telemetry devices in an awake, behaving animal model provides an effective means of gauging sexual function deficits after SCI and could have utility for quantifying recovery after a therapeutic intervention" |
| Keywords: | "Animals;Animals Autonomic Nervous System/*physiopathology Chronic Disease Disease Models, Animal Erectile Dysfunction/*diagnosis/etiology/physiopathology Male *Penile Erection Penis/*innervation Pressure Rats, Wistar *Sexual Behavior, Animal Spinal Cord Injuries/;" |
| Notes: | "MedlineSteadman, Casey J Vangoor, Sai S Hubscher, Charles H eng Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. 2019/09/05 Am J Physiol Regul Integr Comp Physiol. 2019 Nov 1; 317(5):R673-R683. doi: 10.1152/ajpregu.00171.2019. Epub 2019 Sep 4" |
