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Chem Senses

Title:		Oxaspiropentane derivatives as effective sex pheromone analogues in the gypsy moth: electrophysiological and behavioral evidence
Author(s):		Solari P; Crnjar R; Frongia A; Sollai G; Secci F; Spiga M; Masala C; Liscia A;
Address:		"Department of Experimental Biology, Section of General Physiology, University of Cagliari, Cittadella Universitaria, SS 554 Km 4.5, Monserrato, Cagliari 09042, Italy"
Journal Title:		Chem Senses
Year:		2007
Volume:		20070714
Issue:		8
Page Number:		755 - 763
DOI:		10.1093/chemse/bjm043
ISSN/ISBN:		0379-864X (Print) 0379-864X (Linking)
Abstract:		"A number of oxaspiropentane derivatives (OXPs) were tested as potential (+)-disparlure analogues, with the aim of identifying any possible interaction of these compounds, be it additive, synergetic, or inhibitory, with the pheromone response in the male gypsy moth Lymantria dispar. As assessed by male electroantennograms, 2 OXPs, 2-decyl-1-oxaspiro[2.2]pentane (OXP-01) and 4-(1-oxaspiro[2.2]pent-2-yl)butan-1-ol (OXP-04), were found to be effective. OXP-01 had no stimulatory effect but strongly decreased the response to (+)-disparlure in a blend in a 1:1 ratio. By contrast, OXP-04 proved to be more stimulating than (+)-disparlure and also had an additive effect in the blend. Single-cell recordings from the sensilla trichoidea showed the activity of 2 cells, one of which responded to (+)-disparlure. OXP-01 reduced the stimulating effectiveness of pheromone by silencing the pheromone-responding unit when the 2 compounds were presented in blend, whereas OXP-04 mimicked the pheromone response, evidenced by exciting the pheromone-responding neuron when tested alone. Behavioral observations are in agreement with electrophysiological results"
Keywords:		"Air Animals Behavior, Animal Dose-Response Relationship, Drug Electrophysiology/*methods Epoxy Compounds/*chemistry Female Male Models, Chemical Moths Odorants Pheromones Sex Attractants/*metabolism Sexual Behavior, Animal Spiro Compounds/*chemistry Time;"
Notes:		"MedlineSolari, Paolo Crnjar, Roberto Frongia, Angelo Sollai, Giorgia Secci, Francesco Spiga, Marco Masala, Carla Liscia, Anna eng Research Support, Non-U.S. Gov't England 2007/07/17 Chem Senses. 2007 Oct; 32(8):755-63. doi: 10.1093/chemse/bjm043. Epub 2007 Jul 14"