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Toxicol Sci

Title:		Prenatal Exposure to Bisphenol A Analogues on Female Reproductive Functions in Mice
Author(s):		Shi M; Sekulovski N; MacLean JA; Whorton A; Hayashi K;
Address:		"Department of Physiology, Southern Illinois University School of Medicine, Carbondale, Illinois 62901"
Journal Title:		Toxicol Sci
Year:		2019
Volume:		168
Issue:		2
Page Number:		561 - 571
DOI:		10.1093/toxsci/kfz014
ISSN/ISBN:		1096-0929 (Electronic) 1096-0929 (Linking)
Abstract:		"This study was performed to examine whether prenatal exposure to bisphenol (BP) A analogues, BPE and BPS, negatively impacts female reproductive functions and follicular development using mice as a model. CD-1 mice were orally exposed to control treatment (corn oil), BPA, BPE, or BPS (0.5, 20, or 50 microg/kg/day) from gestational day 11 (the presence of vaginal plug = 1) to birth. Exposure to BPA, BPE, and BPS accelerated the onset of puberty and exhibited abnormal estrous cyclicity, especially with lower doses. Females exposed to BPA, BPE, and BPS exhibited mating difficulties starting at 6 months of age. By 9 months, mice exhibited various fertility problems including reduced pregnancy rate, parturition issues, and increased dead pups at birth. Furthermore, the levels of serum testosterone were elevated by BPE or BPS exposure at the age of 9 months, whereas estrogen levels were not affected. On the other hand, the dysregulated expression of steroidogenic enzymes was observed in the ovary at 3, 6, or 9 months of age by BPE or BPS exposure. When we examined neonatal ovary on postnatal day 4, BPA, BPE, and BPS exposure inhibited germ cell nest breakdown and reduced number of primary and secondary follicles. These results suggest that prenatal exposure to BPA analogues, BPE, and BPS, have effects on fertility in later reproductive life probably due to the disruption of early folliculogenesis"
Keywords:		"Animals Benzhydryl Compounds/*toxicity Dose-Response Relationship, Drug Environmental Pollutants/*toxicity Estradiol/blood Estrous Cycle/*drug effects Female Fertility/*drug effects Male Mice, Inbred Strains Ovarian Follicle/*drug effects Phenols/*toxicit;"
Notes:		"MedlineShi, Mingxin Sekulovski, Nikola MacLean, James A Whorton, Allison Hayashi, Kanako eng 2019/01/11 Toxicol Sci. 2019 Apr 1; 168(2):561-571. doi: 10.1093/toxsci/kfz014"