| Title: | Repeated exposure to kairomone-containing coffee odor improves abnormal olfactory behaviors in heterozygous oxytocin receptor knock-in mice |
| Author(s): | Osada K; Kujirai R; Hosono A; Tsuda M; Ohata M; Ohta T; Nishimori K; |
| Address: | "Department of Food Bioscience and Biotechnology, College of Bioresource Sciences, Nihon University, Fujisawa, Japan. The Research Institute of Health Science, Health Sciences University of Hokkaido, Tobetsu, Japan. Department of Molecular and Cell Biology, Graduate School of Agricultural Science, Tohoku University, Sendai, Japan" |
| DOI: | 10.3389/fnbeh.2022.983421 |
| ISSN/ISBN: | 1662-5153 (Print) 1662-5153 (Electronic) 1662-5153 (Linking) |
| Abstract: | "The oxytocin receptor (OXTR) knockout mouse is a model of autism spectrum disorder, characterized by abnormalities in social and olfactory behaviors and learning. Previously, we demonstrated that OXTR plays a crucial role in regulating aversive olfactory behavior to butyric acid odor. In this study, we attempted to determine whether coffee aroma affects the abnormal olfactory behavior of OXTR-Venus knock-in heterozygous mice [heterozygous OXTR (+/-) mice] using a set of behavioral and molecular experiments. Four-week repeated exposures of heterozygous OXTR (+/-) mice to coffee odor, containing three kairomone alkylpyrazines, rescued the abnormal olfactory behaviors compared with non-exposed wild-type or heterozygous OXTR (+/-) mice. Increased Oxtr mRNA expression in the olfactory bulb and amygdala coincided with the rescue of abnormal olfactory behaviors. In addition, despite containing the kairomone compounds, both the wild-type and heterozygous OXTR (+/-) mice exhibited a preference for the coffee odor and exhibited no stress-like increase in the corticotropin-releasing hormone, instead of a kairomone-associated avoidance response. The repeated exposures to the coffee odor did not change oxytocin and estrogen synthetase/receptors as a regulator of the gonadotropic hormone. These data suggest that the rescue of abnormal olfactory behaviors in heterozygous OXTR (+/-) mice is due to the coffee odor exposure-induced OXTR expression" |
| Keywords: | Y-maze avoidance olfactory behavior oxytocin receptor rescued abnormality; |
| Notes: | "PubMed-not-MEDLINEOsada, Kazumi Kujirai, Riyuki Hosono, Akira Tsuda, Masato Ohata, Motoko Ohta, Tohru Nishimori, Katsuhiko eng Switzerland 2023/02/24 Front Behav Neurosci. 2023 Feb 1; 16:983421. doi: 10.3389/fnbeh.2022.983421. eCollection 2022" |
