| Title: | Validation of selected analytical methods using accuracy profiles to assess the impact of a Tobacco Heating System on indoor air quality |
| Author(s): | Mottier N; Tharin M; Cluse C; Crudo JR; Lueso MG; Goujon-Ginglinger CG; Jaquier A; Mitova MI; Rouget EGR; Schaller M; Solioz J; |
| Address: | "Philip Morris International R&D, Philip Morris Products SA (part of Philip Morris International group of companies), Quai Jeanrenaud 5, 2000 Neuchatel, Switzerland. Philip Morris International R&D, Philip Morris Products SA (part of Philip Morris International group of companies), Quai Jeanrenaud 5, 2000 Neuchatel, Switzerland. Electronic address: maya.mitova@pmi.com" |
| DOI: | 10.1016/j.talanta.2016.05.022 |
| ISSN/ISBN: | 1873-3573 (Electronic) 0039-9140 (Linking) |
| Abstract: | "Studies in environmentally controlled rooms have been used over the years to assess the impact of environmental tobacco smoke on indoor air quality. As new tobacco products are developed, it is important to determine their impact on air quality when used indoors. Before such an assessment can take place it is essential that the analytical methods used to assess indoor air quality are validated and shown to be fit for their intended purpose. Consequently, for this assessment, an environmentally controlled room was built and seven analytical methods, representing eighteen analytes, were validated. The validations were carried out with smoking machines using a matrix-based approach applying the accuracy profile procedure. The performances of the methods were compared for all three matrices under investigation: background air samples, the environmental aerosol of Tobacco Heating System THS 2.2, a heat-not-burn tobacco product developed by Philip Morris International, and the environmental tobacco smoke of a cigarette. The environmental aerosol generated by the THS 2.2 device did not have any appreciable impact on the performances of the methods. The comparison between the background and THS 2.2 environmental aerosol samples generated by smoking machines showed that only five compounds were higher when THS 2.2 was used in the environmentally controlled room. Regarding environmental tobacco smoke from cigarettes, the yields of all analytes were clearly above those obtained with the other two air sample types" |
| Keywords: | "Air Pollutants/analysis Air Pollution, Indoor/*analysis *Hot Temperature Nicotine/analysis Particulate Matter/analysis Pyridines/analysis *Tobacco Tobacco Products Tobacco Smoke Pollution/*analysis Volatile Organic Compounds/analysis Accuracy profile Aero;" |
| Notes: | "MedlineMottier, Nicolas Tharin, Manuel Cluse, Camille Crudo, Jean-Rene Lueso, Maria Gomez Goujon-Ginglinger, Catherine G Jaquier, Anne Mitova, Maya I Rouget, Emmanuel G R Schaller, Mathieu Solioz, Jennifer eng Validation Study Netherlands 2016/06/28 Talanta. 2016 Sep 1; 158:165-178. doi: 10.1016/j.talanta.2016.05.022. Epub 2016 May 10" |
