| Title: | A phosphatidylinositol-3-OH kinase family member regulating longevity and diapause in Caenorhabditis elegans |
| Author(s): | Morris JZ; Tissenbaum HA; Ruvkun G; |
| Address: | "Department of Molecular Biology, Massachusetts General Hospital, Boston 02114, USA" |
| ISSN/ISBN: | 0028-0836 (Print) 0028-0836 (Linking) |
| Abstract: | "A pheromone-induced neurosecretory pathway in Caenorhabditis elegans triggers developmental arrest and an increase in longevity at the dauer diapause stage. The gene age-1 is required for non-dauer development and normal senescence. age-1 encodes a homologue of mammalian phosphatidylinositol-3-OH kinase (PI(3)K) catalytic subunits. Lack of both maternal and zygotic age-1 activity causes dauer formation, whereas animals with maternal but not zygotic age-1 activity develop as non-dauers that live more than twice as long as normal. These data suggest that phosphatidylinositol signalling mediated by AGE-1 protein controls lifespan and the dauer diapause decision" |
| Keywords: | Amino Acid Sequence Animals Caenorhabditis elegans/*enzymology/genetics/physiology *Caenorhabditis elegans Proteins Chromosome Mapping Helminth Proteins/genetics/*physiology Longevity/*physiology Molecular Sequence Data Mutation Phosphatidylinositol 3-Kin; |
| Notes: | "MedlineMorris, J Z Tissenbaum, H A Ruvkun, G eng Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. England 1996/08/08 Nature. 1996 Aug 8; 382(6591):536-9. doi: 10.1038/382536a0" |
