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Front Neuroanat

Title:		Postnatal characterization of cells in the accessory olfactory bulb of wild type and reeler mice
Author(s):		Martin-Lopez E; Corona R; Lopez-Mascaraque L;
Address:		"Department of Molecular, Cellular, and Developmental Neurobiology, Instituto Cajal (CSIC) Madrid, Spain"
Journal Title:		Front Neuroanat
Year:		2012
Volume:		20120522
Issue:
Page Number:		15 -
DOI:		10.3389/fnana.2012.00015
ISSN/ISBN:		1662-5129 (Electronic) 1662-5129 (Linking)
Abstract:		"Olfaction is the most relevant chemosensory sense of the rodents. General odors are primarily detected by the main olfactory system while most pheromonal signals are received by the accessory olfactory system. The first relay in the brain occurs in the olfactory bulb, which is subdivided in the main and accessory olfactory bulb (MOB/AOB). Given that the cell generation time is different between AOB and MOB, and the cell characterization of AOB remains limited, the goal of this work was first, the definition of the layering of AOB/MOB and second, the determination of cellular phenotypes in the AOB in a time window corresponding to the early postnatal development. Moreover, since reelin (Reln) deficiency has been related to olfactory learning deficits, we analyzed reeler mice. First, we compared the layering between AOB and MOB at early embryonic stages. Then, cell phenotypes were established using specific neuronal and glial markers as well as the Reln adaptor protein Dab1 to analyse differences in both genetic backgrounds. There was no apparent difference in the cell phenotypes among AOB and MOB or between wild type (wt) and reeler animals. However, a disruption in the granular cell layer of reeler with respect to wt mice was observed. In conclusion, the AOB in Reln-deficient mice showed similar neuronal and glial cell types being only affected the organization of granular neurons"
Keywords:		cell characterization granular cells layering main olfactory bulb postnatal development reelin;
Notes:		"PubMed-not-MEDLINEMartin-Lopez, Eduardo Corona, Rebeca Lopez-Mascaraque, Laura eng Switzerland 2012/06/05 Front Neuroanat. 2012 May 22; 6:15. doi: 10.3389/fnana.2012.00015. eCollection 2012"