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FEBS Lett

Title:		Peroxisome proliferator-activated receptor gamma1 (PPAR-gamma1) as a major PPAR in a tissue in which estrogen induces peroxisome proliferation
Author(s):		Ma H; Tam QT; Kolattukudy PE;
Address:		"The Ohio State University, Neurobiotechnology Center and Department of Biochemistry, Columbus 43210, USA"
Journal Title:		FEBS Lett
Year:		1998
Volume:		434
Issue:		3
Page Number:		394 - 400
DOI:		10.1016/s0014-5793(98)01017-5
ISSN/ISBN:		0014-5793 (Print) 0014-5793 (Linking)
Abstract:		"Estradiol administration induces peroxisome proliferation and the production of 3-hydroxy fatty acid pheromones in the uropygial glands of the duck, but not in the goose gland, which does not produce such pheromones. We isolated a peroxisome proliferator-activated receptor (PPAR)gamma1 cDNA from a duck uropygial gland cDNA library. Northern blots revealed two transcripts, PPAR gamma1 and gamma2, and showed that PPAR gamma was expressed at higher levels than PPAR alpha in the uropygial gland of the duck. Although PPAR gamma2 was expressed in both duck and goose uropygial gland, PPAR gamma1 was expressed only in the duck gland, which responds to estrogen by peroxisome proliferation. In NIH 3T3 transfected cells, PPAR gamma1 was activated by peroxisome proliferators such as Wy-14643, clofibric acid and Ly-171883 causing induction of the target marker gene. By cotransfection with a plasmid containing alpha-cis-retinoic acid receptor RXR alpha, the induction increased up to 9-fold. These results suggest that PPAR gamma1 may be involved in peroxisome proliferation while PPAR gamma2 may be involved in lipid metabolism"
Keywords:		"3T3 Cells Amino Acid Sequence Animals Base Sequence Blotting, Northern Cloning, Molecular DNA Primers DNA, Complementary Ducks Estrogens/*pharmacology Humans Mice Microbodies/*drug effects/metabolism Molecular Sequence Data Receptors, Cytoplasmic and Nucl;"
Notes:		"MedlineMa, H Tam, Q T Kolattukudy, P E eng CA58035/CA/NCI NIH HHS/ Research Support, U.S. Gov't, P.H.S. England 1998/09/22 FEBS Lett. 1998 Sep 4; 434(3):394-400. doi: 10.1016/s0014-5793(98)01017-5"