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Trends Biotechnol

Title:		Synthetic biology applications of the yeast mating signal pathway
Author(s):		Liu Y; Huang Y; Lu R; Xin F; Liu G;
Address:		"College of Biological and Pharmaceutical Engineering, Nanjing Tech University, Jiangsu Province, China. College of Biological and Pharmaceutical Engineering, Nanjing Tech University, Jiangsu Province, China; Jiangsu Synergetic Innovation Center for Advanced Bio-Manufacture, Nanjing Tech University, Jiangsu Province, China. Electronic address: 360265597@njtech.edu.cn"
Journal Title:		Trends Biotechnol
Year:		2022
Volume:		20211016
Issue:		5
Page Number:		620 - 631
DOI:		10.1016/j.tibtech.2021.09.007
ISSN/ISBN:		1879-3096 (Electronic) 0167-7799 (Linking)
Abstract:		"Cell fusion is a fundamental biological process that is involved in the development of most eukaryotic organisms. During the fusion process in Saccharomyces cerevisiae, cells respond to pheromones to trigger the MAPK (mitogen-activated protein kinase) cascade to initiate mating, followed by polarization, cell-wall remodeling, membrane fusion, and karyogamy. We highlight the applications of the yeast mating signal pathway in promoter engineering for tuning the expression of output genes, as well as in metabolic engineering for decoupling growth and metabolism, biosensors for sensitive detection and signal amplification, genetic circuits for programmable biological functionalities, and artificial consortia for cell-cell communication. Strategies such as exploiting rational engineering of modular circuits and optimizing the reproductive pathway to precisely maneuver physiological events have implications for scientific research and industrial development"
Keywords:		Cell Communication *Saccharomyces cerevisiae/genetics/metabolism *Saccharomyces cerevisiae Proteins/genetics/metabolism Signal Transduction/genetics Synthetic Biology Mapk biosensor mating signaling pathway metabolic engineering promoter engineering;
Notes:		"MedlineLiu, Ying Huang, Yuxin Lu, Ran Xin, Fengxue Liu, Guannan eng Research Support, Non-U.S. Gov't Review England 2021/10/21 Trends Biotechnol. 2022 May; 40(5):620-631. doi: 10.1016/j.tibtech.2021.09.007. Epub 2021 Oct 16"