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Front Microbiol

Title:		Quorum sensing gene regulation in Staphylococcus epidermidis reduces the attraction of Aedes aegypti (L.) (Diptera: Culicidae)
Author(s):		Kim D; Crippen TL; Jordan HR; Tomberlin JK;
Address:		"Department of Entomology, Texas A&M University, College Station, TX, United States. Southern Plains Agricultural Research Center, Agricultural Research Service, US Department of Agriculture, College Station, TX, United States. Department of Biological Sciences, Mississippi State University, Starkville, MS, United States"
Journal Title:		Front Microbiol
Year:		2023
Volume:		20230622
Issue:
Page Number:		1208241 -
DOI:		10.3389/fmicb.2023.1208241
ISSN/ISBN:		1664-302X (Print) 1664-302X (Electronic) 1664-302X (Linking)
Abstract:		"INTRODUCTION: Identifying mechanisms regulating mosquito attraction to hosts is key to suppressing pathogen transmission. Historically, the ecology of the host microbial community and its influence on mosquito attraction, specifically, whether bacterial communication through quorum sensing (QS) modulates VOC production that affects mosquito behavior have not been extensively considered. METHODS: Behavioral choice assays were applied along with volatile collection, followed by GC-MS and RNA transcriptome analyses of bacteria with and without a quorum-sensing inhibitor, furanone C-30. RESULTS: Utilizing the quorum-sensing inhibitor on a skin-inhabiting bacterium, Staphylococcus epidermidis, we disrupted its interkingdom communication with adult Aedes aegypti and mitigated their attraction to a blood-meal by 55.1%. DISCUSSION: One potential mechanism suppressing mosquito attraction could be the reduction (31.6% in our study) of bacterial volatiles and their associated concentrations by shifting S. epidermidis metabolic (12 of 29 up regulated genes) and stress (5 of 36 down regulated genes) responses. Manipulating the quorum-sensing pathways could serve as a mechanism to reduce mosquito attraction to a host. Such manipulations could be developed into novel control methods for pathogen-transmitting mosquitoes and other arthropods"
Keywords:		gene regulation interkingdom communication microbes microbial volatile organic compounds mosquito attraction;
Notes:		"PubMed-not-MEDLINEKim, Dongmin Crippen, Tawni L Jordan, Heather R Tomberlin, Jeffery K eng Switzerland 2023/07/10 Front Microbiol. 2023 Jun 22; 14:1208241. doi: 10.3389/fmicb.2023.1208241. eCollection 2023"